Table 3. Upstream factors involved in transcriptional gene alterations by KPT-185, AZD-2014, or KPT-185+AZD-2014 in Jeko-1 cells.

Upstream Regulator	Activation z-score
KPT-185+AZD-2014
Upregulated
TP53	1.534 ± 0.626
ESR1	1.959 ± 0.118
Downregulated
NOD2	−1.510 ± 0.446

Data were analyzed by Ingenuity Pathway Analysis (IPA) based on the transcriptional genes that were consistently altered after indicated treatment inJeko-1 cells.

Values indicate the means ± SEMs of activation z-scores in two independent experiments.