Table 2. Associations observed between clinicopathological variables and OS time in osteosarcoma.
| Factors | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Pooled HR (95%CI) |
P value | Heterogeneity | Pooled HR (95%CI) |
P value | Heterogeneity | |||
| I-squared (%) | Chi-squared (P) | I-squared (%) | Chi-squared (P) | |||||
| Clinicopathological features | ||||||||
| Age | 1.11 (0.86-1.45) | 0.420 | 0.0 | 0.773 | ||||
| Gender | 1.06 (0.83-1.37) | 0.623 | 0.0 | 0.879 | ||||
| Anatomic location | 1.00 (0.76-1.32) | 0.996 | 0.0 | 0.783 | ||||
| Tumor size | 2.03 (1.43-2.88) | 0.000 | 0.0 | 0.773 | ||||
| Tumor stage | 2.86 (2.17-3.77) | 0.000 | 0.0 | 0.740 | 2.69 (2.01-3.59) | 0.000 | 19.1 | 0.284 |
| Distant metastasis | 3.64 (2.70-4.91) | 0.000 | 0.0 | 0.571 | 3.35 (2.48-4.51) | 0.000 | 0.0 | 0.780 |
| Chemotherapy | 1.02 (0.18-5.60)* | 0.987* | 90.1 | 0.001 | 1.28 (0.72-2.27) | 0.396 | 54.0 | 0.140 |
| Expression status | ||||||||
| Up-regulated lncRNAs | 3.24 (2.38-4.40) | 0.000 | 0.0 | 0.813 | 2.17 (1.90-3.87) | 0.000 | 0.0 | 0.979 |
| Down-regulated lncRNAs | 1.52 (0.35-6.61)* | 0.579* | 83.2 | 0.003 | ||||
HR: hazard ratios; CI: confidence intervals. *indicates that data were obtained by using a random-effect model in the meta-analysis.