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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Cell. 2014 Jul 31;158(3):659–672. doi: 10.1016/j.cell.2014.06.050

Figure 7. SIRT6 versus SIRT1-Dependent Circadian Functions.

Figure 7

Scheme representing diverging functions of SIRT6 and SIRT1 in controlling circadian gene expression and metabolism. Different control mechanisms result in a SIRT6- and SIRT1-specific partitioning of the circadian genome that is paralleled by differential metabolic phenotypes.