Abstract
The production of trans-cinnamic acid from various alkylbenzenes by soil microorganisms was studied intensively by use of a co-oxidation technique. The microorganisms were grown on n-paraffins, and they did not use aromatic compounds as a carbon source when the preferred substrate was present in the medium. The effects of cell population, co-oxidation time, and type and mode of addition of the alkylbenzenes on the yield of trans-cinnamic acid were investigated. Yields (5 g/liter) of a product consisting of trans-cinnamic acid (88 to 100%) and 5-phenylvaleric acid (0 to 12%) were obtained when the proper conditions were chosen. Of a variety of microorganisms studied, a soil isolate closely related to Cellulomonas galba was found to be best for the production of trans-cinnamic acid.
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Selected References
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- DAGLEY S., EVANS W. C., RIBBONS D. W. New pathways in the oxidative metabolism of aromatic compounds by microorganisms. Nature. 1960 Nov 12;188:560–566. doi: 10.1038/188560a0. [DOI] [PubMed] [Google Scholar]
- DAVIS J. B., RAYMOND R. L. Oxidation of alkyl-substituted cyclic hydrocarbons by a Nocardia during growth on n-alkanes. Appl Microbiol. 1961 Sep;9:383–388. doi: 10.1128/am.9.5.383-388.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRANKENFELD J. W. THIN-LAYER CHROMATOGRAPHY OF AROMATIC ACIDS. J Chromatogr. 1965 Apr;18:179–180. doi: 10.1016/s0021-9673(01)80344-7. [DOI] [PubMed] [Google Scholar]
- LEADBETTER E. R., FOSTER J. W. Bacterial oxidation of gaseous alkanes. Arch Mikrobiol. 1960;35:92–104. doi: 10.1007/BF00425597. [DOI] [PubMed] [Google Scholar]
- RATLEDGE C., WINDER F. G. The accumulation of salicylic acid by mycobacteria during growth on an iron-deficient medium. Biochem J. 1962 Sep;84:501–506. doi: 10.1042/bj0840501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raymond R. L., Jamison V. W., Hudson J. O. Microbial hydrocarbon co-oxidation. I. Oxidation of mono- and dicyclic hydrocarbons by soil isolates of the genus Nocardia. Appl Microbiol. 1967 Jul;15(4):857–865. doi: 10.1128/am.15.4.857-865.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEBLEY D. M., DUFF R. B., FARMER V. C. Beta-oxidation of fatty acids by Nocardia opaca. J Gen Microbiol. 1955 Oct;13(2):361–369. doi: 10.1099/00221287-13-2-361. [DOI] [PubMed] [Google Scholar]