Table 4. Frequency, rate and rate ratios (RR) for chronic conditions comparing Ewing sarcoma survivors to siblings.
| Condition | Survivors | Siblings | RR (95% CI)* | ||
|---|---|---|---|---|---|
|
| |||||
| # of events | Rate per 10,000 person years | # of events | Rate per 10,000 person years | ||
| Any grade 1-5 | 105 | 555.3 | 1818 | 232.4 | 2.2 (1.8-2.7) |
|
| |||||
| A 2nd grade 1-5 | 57 | 412.6 | 930 | 197.2 | 1.7 (1.3-2.2) |
|
| |||||
| Cardiac | 71 | 134.4 | 586 | 52.8 | 1.8 (1.4-2.3) |
|
| |||||
| Arrhythmias | 31 | 53.2 | 199 | 17.3 | 2.3 (1.6-3.4) |
| Myocardial infarction | 8 | 12.8 | 24 | 2.0 | 5.0 (2.2-11.5) |
| Congestive heart failure | 26 | 43.5 | 18 | 1.5 | 21.5 (11.5-40.1) |
| Hypertension | 40 | 68.2 | 392 | 34.3 | 1.3 (1.0-1.8) |
| Stiff or leaky valve | 13 | 21.1 | 72 | 6.2 | 2.8 (1.6-5.2) |
| Heart complications requiring transplant | 2 | 3.2 | 0 | 0.0 | - |
|
| |||||
| Pulmonary | 57 | 110.8 | 607 | 58.3 | 2.3 (1.7-3.0) |
|
| |||||
| Chronic cough | 29 | 49.2 | 162 | 14.1 | 3.1 (2.0-4.6) |
| Lung fibrosis | 9 | 15.1 | 30 | 2.6 | 5.0 (2.3-10.8) |
| Emphysema | 23 | 38.6 | 438 | 41.1 | 1.4 (0.9-2.2) |
| Other respiratory conditions | 6 | 9.7 | 24 | 2.0 | 5.2 (2.0-13.4) |
| Blood clot in head, lung, arm, leg or pelvis | 12 | 19.4 | 60 | 5.1 | 2.8 (1.5-5.2) |
| Lung complications requiring transplant | 0 | 0.0 | 0 | 0.0 | - |
|
| |||||
| Musculoskeletal | 58 | 125.4 | 90 | 7.7 | 18.1 (12.8-25.7) |
|
| |||||
| Amputation | 22 | 39.2 | 18 | 1.5 | 29.7 (14.9-59.2) |
| Joint replacement | 13 | 21.1 | 14 | 1.2 | 14.1 (6.5-30.7) |
| Osteoporosis | 16 | 27.2 | 38 | 3.2 | 10.4 (5.6-19.3) |
| Scoliosis surgery | 6 | 9.7 | 17 | 1.4 | 8.7 (3.3-22.9) |
| Leg lengthening | 19 | 31.7 | 6 | 0.5 | 126.2 (46.5-342.8) |
|
| |||||
| Neurological | 44 | 102.0 | 399 | 35.5 | 2.2 (1.6-3.0) |
|
| |||||
| Pain or weakness | 17 | 31.5 | 104 | 9.0 | 2.8 (1.7-4.7) |
| Paralysis | 7 | 11.6 | 40 | 3.4 | 2.6 (1.1-5.9) |
| Abnormal sensation | 41 | 89.1 | 357 | 31.5 | 2.1 (1.5-2.8) |
*
Adjusted for age (using natural cubic splines), sex, and race/ethnicity.
-
Rate Ratios were not provided because of the zero or one number of events.