Skip to main content
. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Bone. 2017 Jan 20;100:41–49. doi: 10.1016/j.bone.2017.01.017

Table 2.

Potential strategies to upregulate Klotho for treatment of human CKD

Epigenetic increase of endogenous Klotho

  • Demethylation of Klotho gene promoter

  • Deacetylation of Klotho gene promoter
Non-epigenetic increase of endogenous Klotho

  • PPAR-γ agonist

  • Angiotensin II-type I receptor antagonist

  • Statins

  • Active vitamin D derivatives

  • Intermedin
Delivery of Kotho gene in vivo

  • Viral carrier of Klotho cDNA

  • Klotho cDNA
Administration of exogenous Klotho protein

  • Recombinant Klotho protein

CKD: chronic kidney disease;