Fig. 2.

Serum antibody response to RSV F protein.

The sera were subjected to ELISA coating RSV F protein. Series of detection antibody labeled with HRP were used to acquire the profile of IgG subclasses specific to RSV F protein. A left panel represents concentration of total IgG, IgG1, IgG2 and IgG3 for RSV F in acute phase or convalescent phase, and a right panel does the GMRs C/A of F IgGtotal, IgG1, IgG2, and IgG3. The mean ± 95% CI was estimated by the linear model, and were shown in the graphs. Concentration of antibody in acute phase: 0–3 mo, n = 29; 4–6 mo, n = 28; 7–12 mo, n = 29; 13–18 mo, n = 34; 19–36 mo, n = 35; adults, n = 23. Concentration of antibody in convalescent phase: 0–3 mo, n = 28; 4–6 mo, n = 30; 7–12 mo, n = 33; 13–18 mo, n = 35; 19–36 mo, n = 34; adults, n = 23. GMRs C/A: 0–3 mo, n = 23; 4–6 mo, n = 28; 7–12 mo, n = 28; 13–18 mo, n = 34; 19–36 mo, n = 34; adults, n = 23. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.