Table 1.

Overlapping genes between TBI hippocampal signatures or KDs and human GWAS genes of brain disorders. Human GWAS candidate genes were derived from the GWAS catalog (p < 1e-5).

GWAS disease	Overlapping gene in TBI hippocampal signature
Alcohol consumption/dependence	CUX2; SLC26A4; ZDHHC21; ESR1; SERINC2
AD	APOE; NMU; PCDH11X; PPP1R3B; PROX1; SCARA3; SMC2; TTLL7; ADAMTS9; ARHGAP20; CAMK4; ELMO1; LIPC; PDE7B; PLEKHG1; SP6
ADHD	BCL11A; CDH13; LRRC7; LYPLAL1; NR4A2; SEMA3A; TCEB1; TGFB2; TSHZ2; ZIC5; PAWR; NDN, ESRRB; ADAMTS2; LRRN3; TYRP1
Bipolar disorder	ANK3; COLEC12; DGKH; DPP10; IRF2BP2; ITIH3; MRPS23; MSI2; NFIA; PDE10A; PGM5; PPM1M; SIAE; SP8; TTC39B; UACA; CGNL1; DMTF1; FAT4
Bipolar disorder and schizophrenia	ARC; ATP6V1B2; BAI1; CACNA2D1; CMYA5; COMMD10; CST7; CTNND2; DDX52; DMD; HACE1; IRX1; KAT2B; MRVI1; MYO1E; PRKCQ; PTPRN2; SIM1; SLC39A12; TMEM212; TTC39B; VPS13C
Brain connectivity	CNTN4; EPHA7; NEDD4
Brain structure	BOK; CADPS2; GRIN2B
Cognitive function	PTPRO; AFAP1L2; CDH13; FAT4; GABRQ; GRIN2B; HCCS; IMMP2L; IRX1; IRX2; JUN; KIAA1217; KLHL1; LHX2; LIPC; MCTP2; NR2F2; PLCB1; RIT2; TOX; TSHZ3; UNC13C; VANGL2; ZNF788; LMO4
Word reading	NOS1AP; TACSTD2; TYRP1
Working memory	CLDN1; DRD2; LPHN3
Conduct disorder	C1QTNF7; MCTP2; NR2F2; RIT2; ST8SIA4; ZBTB16; KCNA5; PDE10A
Eating disorders	CAMK1D; DLGAP1
Hippocampal atrophy/volume	APOE; COL18A1; F5; MAGI2; MAL2; DPP4; MSRB3
Intelligence	CNTN4; COL1A2; GYPC; KIF16B
Major depressive disorder	ADCYAP1R1; CCND2; CDH9; EMP1; GRIN2B; HAPLN1; HOMER1; IGFBP3; KCNH5; NDFIP2; NEUROD6; PCLO; RASGEF1B; ATP6V1B2
Parkinson's disease	BMP4; DLG2; GPRIN3; RIT2; RORA; SEMA5A; STK39; VPS13C; WNT3
PTSD	COBL; PCSK2; PRKCA; SLC4A5
Schizophrenia	ANK3; BMP7; CDH13; CXCL12; GNAL; NRGN; PCDH20; PDC; PTGS2; RORA; SNX7; TCF4; VPS13C
Smoking behavior	BDNF; CHRNA3; CHRNA5; KCND2; MAOB; PDE1C