Abstract
This paper presents the results of a study on the antifungal activity of isothiocyanates—derivatives of biphenyl (group “A”), of stilbene (“B”), of azobenzene and benzeneazonaphthalene (“C”), of naphthalene (“D”), and of further polycondensed aromatic hydrocarbons (“E”). From a total of 48 investigated compounds, antifungal activity was observed only in A and D group compounds. B, C, and E group derivatives are extremely insoluble in water, and the molecules are very large; as a result, they probably cannot pass into spores or mycelium of fungi. Thus, the —NCS group cannot manifest its reactivity.
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- BALAN J., DROBNICA L. Cancerostatic action of beta-naphtylisothiocyanate on skin carcinoma of mice (Preliminary report). Neoplasma. 1961;8:127–129. [PubMed] [Google Scholar]
- Bacíková D., Nemec P., Drobnica L., Antos K., Kristián P., Hulka A. Antiworm activity of some natural and synthetic compounds. I. Effect of aliphatic and mononuclear aromatic isothiocyanates on Turbatrix aceti. J Antibiot (Tokyo) 1965 Jul;18(4):162–170. [PubMed] [Google Scholar]
- Drobnica L., Zemanová M., Nemec P., Antos K., Kristián P., Stullerová A., Knoppová V., Nemec P., Jr Antifungal activity of isothiocyanates and related compounds. I. Naturally occurring isothiocyanates and their analogues. Appl Microbiol. 1967 Jul;15(4):701–709. doi: 10.1128/am.15.4.701-709.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Drobnica L., Zemanová M., Nemec P., Kristián P., Antos K., Hulka A. Antifungal activity of isothiocyanates and related compounds. II. Mononuclear aromatic isothiocyanates. Appl Microbiol. 1967 Jul;15(4):710–717. doi: 10.1128/am.15.4.710-717.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOPEZ M., MAZZANTI L. Experimental investigations on alpha-naphthyl-iso-thiocyanate as a hyperplastic agent of the biliary ducts in the rat. J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):243–250. doi: 10.1002/path.1700690132. [DOI] [PubMed] [Google Scholar]
- NEMEC P., DROBNICA L., ANTOS K., KRISTIAN P., HULKA A., HORAKOVA K. Cancerostatic action of beta-naphtylisothiocyanate. Neoplasma. 1958;5(2):207–208. [PubMed] [Google Scholar]
- UNGAR H., MORAN E., EISNER M., ELIAKIM M. Rat intrahepatic biliary tract lesions from alpha-naphthyl isothiocyanate. Arch Pathol. 1962 May;73:427–435. [PubMed] [Google Scholar]