Abstract
Prasinomycin, a new antibiotic from the green spore streptomycete, Streptomyces prasinus, primarily inhibits the growth of gram-positive microorganisms. Like penicillin, it is effective only against growing cells. Though primarily bacteriostatic at levels about the minimal inhibitory concentration, it is bactericidal at higher levels. Neither synergism nor antagonism could be demonstrated for prasinomycin with a variety of other antibiotics. It is highly active upon subcutaneous administration to mice infected with Staphylococcus aureus, Streptococcus pyogenes C203, or Diplococcus pneumoniae. Prasinomycin has a unique prophylactic action whereby one dose protects mice against experimental infections for as long as 2 months. It is more effective against S. aureus infections in mice when administered subcutaneously 20 hr prior to infection than when given in divided doses 1 hr before and 4 hr after infection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Huber G., Schacht U., Weidenmüller H. L., Schmidt-Thomé J., Duphorn J., Tschesche R. Meonomycin, a new antibiotic. II. Characterization and chemistry. Antimicrob Agents Chemother (Bethesda) 1965;5:737–742. [PubMed] [Google Scholar]
- Lumb M., Macey P. E., Spyvee J., Whitmarsh J. M., Wright R. D. Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity, from a species of Streptomyces (C2989). Nature. 1965 Apr 17;206(981):263–265. doi: 10.1038/206263a0. [DOI] [PubMed] [Google Scholar]
- Meyers E., Smith D. A., Perlman D. Combined action of vernamycin A and other antibiotics. Antimicrob Agents Chemother (Bethesda) 1965;5:256–260. [PubMed] [Google Scholar]
- Miraglia G. J., Basch H. I. Activity of selected penicillins in vitro and in experimental bacterial infections in mice. Appl Microbiol. 1967 May;15(3):566–568. doi: 10.1128/am.15.3.566-568.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pansy F. E., Basch H., Jambor W. P., Maestrone G., Semar R., Donovick R. Hamycin: in vitro and in vivo studies. Antimicrob Agents Chemother (Bethesda) 1966;6:399–404. [PubMed] [Google Scholar]
- Wallhausser K. H., Nesemann G., Prave P., Steigler A. Moenomycin, a new antibiotic. I. Fermentation and isolation. Antimicrob Agents Chemother (Bethesda) 1965;5:734–736. [PubMed] [Google Scholar]
- Weisenborn F. L., Bouchard J. L., Smith D., Pansy F., Maestrone G., Miraglia G., Meyers E. The prasinomycins: antibiotics containing phosphorus. Nature. 1967 Mar 18;213(5081):1092–1094. doi: 10.1038/2131092a0. [DOI] [PubMed] [Google Scholar]
- von Wasielewski E., Muschaweck R., Schütze E. Meonomycin, a new antibiotic. 3. Biological properties. Antimicrob Agents Chemother (Bethesda) 1965;5:743–748. [PubMed] [Google Scholar]