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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 2017 Jun 5;114(24):E4897. doi: 10.1073/pnas.1708260114

Correction for Ding et al., Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

PMCID: PMC5474789  PMID: 28584124

MICROBIOLOGY Correction for “Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles,” by Qiang Ding, Brigitte Heller, Juan M. V. Capuccino, Bokai Song, Ila Nimgaonkar, Gabriela Hrebikova, Jorge E. Contreras, and Alexander Ploss, which appeared in issue 5, January 31, 2017, of Proc Natl Acad Sci USA (114:1147–1152; first published January 17, 2017; 10.1073/pnas.1614955114).

The authors wish to note the following: “It has been brought to our attention that the original Fig. 5A in our paper contained a duplicate image in which the panel showing the localization of ORF3 86-88A mutant was duplicated and also shown as ORF3 95-97A mutant. In the corrected version of Fig. 5A shown below, we have replaced the duplicate image with the correct original data. After careful reexamination of the original data, we are confident that the error in assembling this figure does not affect the validity of the research or the conclusions that we have drawn. We are grateful to the careful reader who brought this mistake to our attention and apologize for any confusion that this error may have caused.” The corrected Fig. 5 and its legend appear below.

Fig. 5.

Fig. 5.

Identification of amino acid residues critical for HEV ORF3′s ion channel activity. (A) HepG2C3A cells lentivirally transduced with HA-tagged wild type or the indicated ORF3 mutant were stained with anti-HA and anti-calnexin antibodies. Nuclei were stained with Hoechst dye. Shown are representative images of triplicate experiments. (B) Current–voltage relationship of X. laevis oocytes expressing HEV wild type or the indicated ORF3 mutants. Experiments were conducted as detailed in Fig. 3. Data represent the mean + SD (n = 5).


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