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. 1990 Oct;87(19):7395–7399. doi: 10.1073/pnas.87.19.7395

Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction.

P M Hwang 1, A Verma 1, D S Bredt 1, S H Snyder 1
PMCID: PMC54753  PMID: 2217172

Abstract

To assess the role of phosphatidylinositol turnover in taste transduction we have visualized, in rat tongue, ATP-dependent endoplasmic reticular accumulation of 45Ca2+, inositol 1,4,5-trisphosphate receptor binding sites, and phosphatidylinositol turnover monitored by autoradiography of [3H]cytidine diphosphate diacylglycerol formed from [3H]cytidine. Accumulated 45Ca2+, inositol 1,4,5-trisphosphate receptors, and phosphatidylinositol turnover are selectively localized to apical areas of the taste buds of circumvallate papillae, which are associated with bitter taste. Further evidence for a role of phosphatidylinositol turnover in bitter taste is our observation of a rapid, selective increase in mass levels of inositol 1,4,5-trisphosphate elicited by low concentrations of denatonium, a potently bitter tastant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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