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. 1968 Jul;16(7):1015–1018. doi: 10.1128/am.16.7.1015-1018.1968

Serological Studies of the T and Tumor Antigens of the Oncogenic Simian Adenoviruses

Raymond V Gilden 1,2,3, Jerome Kern 1,2,3, Richard L Heberling 1,2,3, Robert J Huebner 1,2,3
PMCID: PMC547580  PMID: 4298811

Abstract

Tumor-specific antigens and antisera were prepared for eight of the oncogenic simian adenoviruses. Complement-fixation tests revealed three distinct serological subgroups. This grouping was maintained in studies of virus-infected cells (T antigens) although high titered preparations were obtained for only the major subgroup I. The current grouping is as follows: (I) SV1, SV11, SV25, SV33, SV34, SV38; (II) SV20, SV23; (III) SA 7. Antigens from each subgroup were rapidly inactivated at 56 C, and group II and III antigens were also markedly inactivated at 37 C. One of the tumors (SV1) also contained SV40 T antigen, suggesting origin from a simian adenovirus-SV40 “hybrid.”

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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