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. 1968 Aug;16(8):1151–1155. doi: 10.1128/am.16.8.1151-1155.1968

Sensitivity of Herpes Simplex Virus, Vaccinia Virus, and Adenoviruses to Deoxyribonucleic Acid Inhibitors and Thiosemicarbazones in a Plaque Suppression Test

Ernest C Herrmann Jr 1
PMCID: PMC547611  PMID: 4300089

Abstract

Herpes simplex and vaccinia viruses and adenovirus types 1, 2, 5, and 7 were tested by plaque suppression methods for sensitivity to halogenated deoxyuridines (5-iodo-, 5-bromo-, 5-chloro-, and 5-fluoro-), cytosine arabinoside, isatin-β-thiosemicarbazone, and N-methylisatin-β-thiosemicarbazone. After incubation for 12 days in HeLa cell cultures, vaccinia virus plaques were still readily suppressed by deoxyribonucleic acid (DNA) inhibitors and thiosemicarbazones. Herpes simplex virus plaques were likewise suppressed by at least three DNA inhibitors. Adenovirus plaques were not suppressed by DNA inhibitors or thiosemicarbazones. 5-Fluoro-2′-deoxyuridine could not be shown to have any antiviral activity, but it did produce a substantial lethal action on the cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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