Abstract
Intravenous inoculation of mice with vaccinia virus produced characteristic lesions of the tail surface which were suppressed by intraperitoneal administration of interferon and polyacrylic acid (PAA). Polymethacrylic acid (PMAA) stimulated the formation of vaccinia virus lesions. For full activity, both interferon and PAA must be given prior to infection. PAA was still significantly effective at small dose levels (3 mg/kg) and achieved protection for at least 4 weeks. Protection increased with increasing molecular weight of the polymer. The mode of action of PAA is discussed.
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Selected References
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- BRIODY B. A. Response of mice to ectromelia and vaccinia viruses. Bacteriol Rev. 1959 Jun;23(2):61–95. doi: 10.1128/br.23.2.61-95.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boyle J. J., Haff R. F., Stewart R. C. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. Antimicrob Agents Chemother (Bethesda) 1966;6:536–539. [PubMed] [Google Scholar]
- De Somer P., De Clercq E., Billiau A., Schonne E., Claesen M. Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro. J Virol. 1968 Sep;2(9):878–885. doi: 10.1128/jvi.2.9.878-885.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Somer P., De Clercq E., Billiau A., Schonne E., Claesen M. Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo. J Virol. 1968 Sep;2(9):886–893. doi: 10.1128/jvi.2.9.886-893.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Merigan T. C. Induction of circulating interferon by synthetic anionic polymers of known composition. Nature. 1967 Apr 22;214(5086):416–417. doi: 10.1038/214416a0. [DOI] [PubMed] [Google Scholar]
- Wheelock E. F. Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin. Science. 1965 Jul 16;149(3681):310–311. [PubMed] [Google Scholar]