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. 1968 Oct;16(10):1551–1556. doi: 10.1128/am.16.10.1551-1556.1968

Production of Interferon in Mice: Effect of Altered Gaseous Environments

Kun-Yen Huang 1,1, Francis B Gordon 1
PMCID: PMC547702  PMID: 5684205

Abstract

Effects of altered gaseous environments (parabarosis) on interferon production in mice were studied, with Newcastle disease virus (NDV) as the inducer. Increased levels of interferon in lung tissue were observed when mice were exposed to 11% O2 in N2 for 3 days before and after, or only after, injection of NDV. However, serum interferon levels remained unchanged. Exposure of mice to 77% O2 for up to 7 days did not affect the response to interferon induction as assayed in lungs or sera. Interferon levels were significantly depressed in mice exposed to a simulated depth of 213 ft in seawater [with normal partial pressure of O2 (pO2) in N2] for 2 or 4 weeks. Whereas definite depression of interferon was also observed in mice maintained at a simulated altitude of 37,000 ft (with normal pO2) for 2 weeks, those maintained at the same condition for 4 weeks showed a normal level of interferon. The results obtained with hypoxia are compatible with other reports on the influence of O2 tension on viral infection. The factors responsible for alterations observed in interferon level in mice kept in normal pO2, but under altered pressure, have not yet been identified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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