Abstract
1-Methyl-3-nitro-1-nitrosoguanidine was shown to have in vitro antimicrobial activity against fungi and gram-positive and gram-negative bacteria; it was also shown to have in vivo activity in mice experimentally infected with Staphylococcus aureus or Escherichia coli comparable to that observed with penicillin or streptomycin sulfate.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DeVita V. T., Denham C., Davidson J. D., Oliverio V. T. The physiological disposition of the carcinostatic 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in man and animals. Clin Pharmacol Ther. 1967 Jul-Aug;8(4):566–577. doi: 10.1002/cpt196784566. [DOI] [PubMed] [Google Scholar]
- Hunt D. E., Pittillo R. F. Antifungal action of 1,3-bis(2-chloroethyl)-1-nitrosourea. Antimicrob Agents Chemother (Bethesda) 1965;5:710–716. [PubMed] [Google Scholar]
- KILGORE W. W., GREENBERG J. Filament formation and resistane to 1-methyl-3-nitro-1-nitrosoguanidine and other radiomimetic compounds in Escherichia coli. J Bacteriol. 1961 Feb;81:258–266. doi: 10.1128/jb.81.2.258-266.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SKIPPER H. E., SCHABEL F. M., Jr, TRADER M. W., THOMSON J. R. Experimental evaluation of potential anticancer agents. VI. Anatomical distribution of leukemic cells and failure of chemotherapy. Cancer Res. 1961 Oct;21:1154–1164. [PubMed] [Google Scholar]
- Wheeler G. P., Bowdon B. J. Some effects of 1, 3-bis(2-chloroethyl)-1-nitrosourea upon the synthesis of protein and nucleic acids in vivo and in vitro. Cancer Res. 1965 Nov;25(10):1770–1778. [PubMed] [Google Scholar]