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. 2017 Apr 10;7(7):1875–1889. doi: 10.7150/thno.18985

Figure 6.

Figure 6

Brian tumor-targeting efficiency and biodistribution of nanoassemblies. (A) Blood retentions of EGF-SA-AuNPs and EGF-AuNPs in normal mice over 24 h post injection. (B) Biodistribution of EGF-SA-AuNPs and EGF-AuNPs in the brain of U87-bearing mice or normal mice after i.v. injection for 24 h. (C) Distributions of Cy5.5-EGF-SA-AuNPs and Cy5.5-EGF-AuNPs by H&E and silver staining in normal and tumor brain sections. Slices were visualized under an inverted optical microscope with a 100× objective. (D) Confocal images of Cy5.5-EGF-SA-AuNPs and Cy5.5-EGF-AuNPs distributions in brains. Bright field and fluorescence images and their overlays are presented. (E) Silver and H&E staining results of heart, liver, spleen, lung and kidneys. Slices were visualized under an inverted optical microscope with a 200× objective.