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. 2017 Apr 10;7(7):1901–1913. doi: 10.7150/thno.19168

Figure 8.

Figure 8

Inhibition of miR-4260 mitigates tumor growth of implant colorectal cancer (A) qRT-PCRs for miR-4260 expression in HCT116 cells transfected with lentivirus-based miR-4260 sponge versus Fugw control (n=3). (B) Schema for subcutaneous implantation of HCT116 cells into the right flank of nude mice on day 0 and therapeutic injection of lentivirus-based miR-4260 sponge on day 14. (C) qRT-PCRs showed reduced miR-4260 expression level in the xenograft treated with miR-4260 sponge harvested on day 28 (n=5). (D) Tumor volume was measured every other day from the day of treatment with miR-4260 sponge (day 14) until the day of sacrifice (day 28) (n=5). (E) Representative images for general tumor morphology on day 28 (n=5). (F) Immunohistochemical staining for Ki67 and PCNA in the xenograft colorectal cancer tissues (n=5). Magnification=200x. *, p<0.05.