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. 2017 May 12;7(7):1990–2002. doi: 10.7150/thno.18136

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Effect of lipid-PEG on NP uptake by tumor cells and macrophage cells. Uptake kinetics of siRNA NPs with (a) neutral and (b) anionic lipid-PEGs on Luc-HeLa cells. (c) Representative fluorescence images for the tumor cell uptake of NP (DY547-siRNA) with different lipid-PEGs after 24 h incubation. (d) NP uptake on macrophage cells (RAW264.7) after 12 h incubation. The correlation of (e) Luc-HeLa cell uptake and (f) macrophage cell uptake with the dissociation rate constant (k_d) of different lipid-PEGs.