Figure 10.

Nicotine microinjection in STR enhanced TINN-evoked responses in A1. A, Example of NN-evoked current sink enhanced by nicotine microinjection in STR, and subsequently by systemic nicotine (left); graph (right) shows response magnitudes before and after STR microinjection, and inset shows post hoc visualization of fluorescent injection site in STR (horizontal plane; LG, lateral geniculate; RT, reticular nucleus; ACx, auditory cortex). B, Group data (n = 10) showing enhancing effect of nicotine STR microinjections on NN-evoked responses (left). In a subset of six animals that appeared more sensitive to systemic nicotine, STR microinjections were effective, whereas in four animals that were insensitive to systemic nicotine STR microinjections also had no effect (right).