Table 2. Stratification analysis for tumor GGT expression and overall survival of GC patients.
| GC Patients (n=322) | |||
|---|---|---|---|
| No. of Cases | HR (95% CI) | Adjusted HR (95% CI) | |
| TNM stage | |||
| Stage0, I & II | 138 | 1.93 (0.98-3.60) | 1.88 (0.94-3.56) |
| Stage III & IV | 178 | 1.63 (1.11-2.36) | 1.63 (1.10-2.39) |
| Tumor locationa | |||
| Proximal | 59 | 1.26 (0.55-2.60) | 1.19 (0.51-2.59) |
| Body | 67 | 1.21 (0.63-2,27) | 1.48 (0.76-2.85) |
| Distal | 175 | 2.45 (1.51-3.88) | 2.40 (1.46-3.86) |
| Tumor Grade | |||
| Low | 202 | 1.91 (1.27-2.80) | 1.98 (1.31-2.96) |
| Moderate | 78 | 2.20 (1.11-4.24) | 2.09 (1.02-2.96) |
| High | 42 | 1.72 (0.59-5.04) | 2.40 (0.74-7.91) |
| Histological subtype | |||
| Papillary & Tubular | 77 | 2.16 (1.10-4.33) | 2.20 (1.10-4.50) |
| Mucinous & Signet | 84 | 3.81 (1.53-8.25) | 4.0 (1.58-8.87) |
| Ring Cell | |||
| Undifferentiated | 161 | 1.64 (1.05-2.50) | 1.65 (1.04-2.56) |
| Her2 | |||
| Negative | 185 | 1.56 (0.95-2.45) | 1.64 (0.99-2.59) |
| Positive | 94 | 2.41 (1.39-4.18) | 2.42 (1.35-4.35) |
| Chemotherapy | |||
| No | 169 | 2.17 (1.39-3.30) | 2.14 (1.38-3.27) |
| Yes | 153 | 1.54 (0.92-2.47) | 1.52 (0.91-2.48) |
NOTE: Multivariate COX proportional hazard analysis was conducted to evaluate HR of GGT high versus low, tumor GGT low group was used as reference. The HRs were adjusted by sex and age at diagnosis.
*Statistical significant on COX proportional hazard analysis, p<0.05
a,11 cases of “whole” (linitis plastica) are not analyzed due to insufficient numbers.