Table 2. Association of CKIP-1 rs2306235 polymorphism with risk of CHF.
| Models | Genotypes | CHF, n (%) | Control, n (%) | Unadjusted OR (95% CI) | P | Adjusted OR* (95% CI) | P* | |
|---|---|---|---|---|---|---|---|---|
| Entire cohort | ||||||||
| Additive | CC | 736 (79.7) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 176 (19.1) | 155 (15.2) | 1.33 (1.05-1.68) | 0.020 | 1.36 (1.07-1.73) | 0.013 | ||
| GG | 11 (1.2) | 6 (0.6) | 1.46 (0.89-2.41) | 0.136 | 1.43 (0.86-2.38) | 0.163 | ||
| Dominant | CC | 736 (79.7) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 187 (20.3) | 161 (15.8) | 1.36 (1.07-1.71) | 0.010 | 1.38 (1.09-1.75) | 0.007 | ||
| Hypertension | ||||||||
| Additive | CC | 473 (79.2) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 116 (19.4) | 155 (15.2) | 1.36 (1.04-1.77) | 0.024 | 1.43 (1.08-1.88) | 0.012 | ||
| GG | 8 (1.3) | 6 (0.6) | 1.56 (0.91-2.65) | 0.103 | 1.47 (0.85-2.55) | 0.166 | ||
| Dominant | CC | 473 (79.2) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 124 (20.8) | 161 (15.8) | 1.40 (1.08-1.81) | 0.011 | 1.45 (1.11-1.90) | 0.006 | ||
| Nonhypertension | ||||||||
| Additive | CC | 263 (80.7) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 60 (18.4) | 155 (15.2) | 1.26 (0.91-1.76) | 0.162 | 1.25 (0.89-1.75) | 0.199 | ||
| GG | 3 (0.9) | 6 (0.6) | 1.28 (0.64-2.56) | 0.490 | 1.27 (0.62-2.61) | 0.522 | ||
| Dominant | CC | 263 (80.7) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 63 (19.3) | 161 (15.8) | 1.28 (0.93-1.76) | 0.136 | 1.26 (0.90-1.76) | 0.174 | ||
| CHD | ||||||||
| Additive | CC | 550 (79.6) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 133 (19.2) | 155 (15.2) | 1.34 (1.04-1.73) | 0.025 | 1.39 (1.07-1.82) | 0.015 | ||
| GG | 8 (1.2) | 6 (0.6) | 1.44 (0.85-2.46) | 0.177 | 1.37 (0.79-2.38) | 0.267 | ||
| Dominant | CC | 550 (79.6) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 141 (20.4) | 161 (15.8) | 1.37 (1.07-1.76) | 0.014 | 1.41 (1.09-1.83) | 0.010 | ||
| Non-CHD | ||||||||
| Additive | CC | 186 (80.2) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 43 (18.5) | 155 (15.2) | 1.28 (0.88-1.86) | 0.193 | 1.24 (0.84-1.82) | 0.280 | ||
| GG | 3 (1.3) | 6 (0.6) | 1.52 (0.76-3.05) | 0.240 | 1.81 (0.89-3.69) | 0.103 | ||
| Dominant | CC | 186 (80.2) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 46 (19.8) | 161 (15.8) | 1.32 (0.92-1.90) | 0.135 | 1.29 (0.89-1.88) | 0.180 | ||
| Diabetes | ||||||||
| Additive | CC | 185 (79.4) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 47 (20.2) | 155 (15.2) | 1.41 (0.98-2.02) | 0.065 | 1.65 (1.12-2.45) | 0.012 | ||
| GG | 1 (0.4) | 6 (0.6) | 0.88 (0.30-2.54) | 0.813 | 0.72 (0.23-2.21) | 0.561 | ||
| Dominant | CC | 185 (79.4) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 48 (20.6) | 161 (15.8) | 1.38 (0.97-1.98) | 0.076 | 1.59 (1.08-2.35) | 0.019 | ||
| Nondiabetes | ||||||||
| Additive | CC | 551 (79.9) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC | 129 (18.7) | 155 (15.2) | 1.30 (1.00-1.68) | 0.047 | 1.30 (1.00-1.68) | 0.047 | ||
| GG | 10 (1.4) | 6 (0.6) | 1.61 (0.97-2.68) | 0.066 | 1.62 (0.97-2.70) | 0.065 | ||
| Dominant | CC | 551 (79.9) | 859 (84.2) | 1.00 (reference) | 1.00 (reference) | |||
| GC/GG | 139 (21.4) | 161 (15.8) | 1.35 (1.05-1.73) | 0.020 | 1.35 (1.05-1.73) | 0.021 | ||
OR: odd ratio; CI: confidence interval. CHD: Coronary heart disease. *Adjusted for age, gender, smoking status, and dyslipidemia.