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Model of Fgf10 and Sox9 function during salivary gland budding and branching morphogenesis. Sox9 is required for branching initiation by promoting the formation of distal epithelial progenitors and their proliferation. Mesenchymal Fgf10 maintains epithelial Sox9 expression during salivary gland development by activating the Erk pathway through Fgfr2.
