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. 2017 Jun 24;19(8):595–605. doi: 10.1016/j.neo.2017.04.006

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Elevated CD8 T cells in Stat6-deficient ApcMin/+ correlates with downregulation of PD-1 on CD4 T cells. (A and B) Splenocytes and lamina propria cells from ApcMin/+ (n = 6), ApcMin/+ Stat6+/− mice (n = 8), and ApcMin/+ Stat6−/− mice (n = 8) were analyzed for CD4 and CD8 T cells. Student’s t test was used to determine statistical significance. (C) Lamina propria cells from the above groups were analyzed for CD4 T cells expressing PD-1. * P < .05, ** P < .005, *** P < .0005, **** P < .0005.