Table 2. Staging and risk stratification of medulloblastomas.
Modified Chang Staging | |||
---|---|---|---|
T stage | M stage | ||
T1 | Tumor <3 cm in diameter | M0 | No evidence of gross subarachnoid or
hematogenous metastasis |
T2 | Tumor ≥3 cm in diameter | M1 | Microscopic tumor cells found in CSF |
T3a | Tumor >3 cm and with extension
into aqueduct of Sylvius or foramen of Luschka |
M2 | Gross nodular seeding intracranially
beyond the primary site (in cerebellar/cerebral subarachnoid space or in third or lateral ventricle) |
T3b | Tumor >3 cm and with
unequivocal extension into brainstem |
M3 | Gross nodular seeding in spinal
subarachnoid space |
T4 | Tumor >3 cm with extension past
aqueduct of Sylvius or down past foramen magnum |
M4 | Metastasis outside cerebrospinal axis |
Risk Stratification | |||
Standard (Average) Risk (66%) | High Risk (34%) | ||
>3 years old | <3 years old | ||
<1.5 cm 2
residual disease after resection |
Subtotal resection, >1.5 cm 2 residual tumor | ||
M0 by craniospinal MRI and CSF | M+, leptomeningeal seeding,
and location outside of the posterior fossa |
CSF, cerebrospinal fluid; MRI, magnetic resonance imaging.