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. 2017 Apr 13;6:490. [Version 1] doi: 10.12688/f1000research.10859.1

Table 2. Staging and risk stratification of medulloblastomas.

Modified Chang Staging
T stage M stage
T1 Tumor <3 cm in diameter M0 No evidence of gross subarachnoid or
hematogenous metastasis
T2 Tumor ≥3 cm in diameter M1 Microscopic tumor cells found in CSF
T3a Tumor >3 cm and with extension
into aqueduct of Sylvius or
foramen of Luschka
M2 Gross nodular seeding intracranially beyond the
primary site (in cerebellar/cerebral subarachnoid
space or in third or lateral ventricle)
T3b Tumor >3 cm and with
unequivocal extension into
brainstem
M3 Gross nodular seeding in spinal subarachnoid
space
T4 Tumor >3 cm with extension past
aqueduct of Sylvius or down
past foramen magnum
M4 Metastasis outside cerebrospinal axis
Risk Stratification
Standard (Average) Risk (66%) High Risk (34%)
>3 years old <3 years old
<1.5 cm 2 residual disease after
resection
Subtotal resection, >1.5 cm 2 residual tumor
M0 by craniospinal MRI and CSF M+, leptomeningeal seeding, and location outside of
the posterior fossa

CSF, cerebrospinal fluid; MRI, magnetic resonance imaging.