Overview of the methods used in the CASP11 contact-assisted “Ts” category. A: Overall flowchart. B: Contacts provided by organizers for top: all-β protein (Ts763) and bottom: all-α protein (Ts777). Non-ambiguous contacts are represented as yellow bands within the native structure, and non-ambiguous and all contacts are represented as contact maps. C: Change in models as iterative hybridize protocol proceeds for Ts763. (i) starting models (from iterative annealing, GDT-TS5 46.9), (ii) optimization with non-ambiguous restraints (GDT-TS5 56.7), (iii) after maximum ambiguity increased to 5 (GDT-TS5 67.5), and (iv) the final structure optimized with full-ambiguity (GDT-TS579.6).