Establishment of a Disease-Specific Graded Prognostic Assessment for Hepatocellular Carcinoma Patients with Spinal Metastasis

Abstract

Background/Aims

Hepatocellular carcinoma (HCC) patients with spinal metastasis (SM) show heterogeneous lengths of survival. In this study, we develop and propose a graded prognostic assessment for HCC patients with SM (HCC-SM GPA).

Methods

We previously reported the outcomes of 192 HCC patients with SM who received radiotherapy from April 1992 to February 2012. Prognostic factors that significantly affected survival in that study were used to establish the HCC-SM GPA. Validation was performed using an independent cohort of 63 patients recruited from September 2011 to March 2016.

Results

We developed the HCC-SM GPA using the following factors: Eastern Cooperative Oncology Group performance status (0–2, 0 point; 3–4, 1 point), controlled primary HCC (yes, 0 point; no, 2 points), and extrahepatic metastases other than bone (no, 0 point; yes, 1 point). Patients were stratified into low (GPA=0), intermediate (GPA=1 to 2), and high risk (GPA=3 to 4). When applied to the validation cohort, the HCC-SM GPA determined median survival durations of 13.6, 4.8, and 2.6 months and 1-year overall survival rates of 58.3%, 17.8%, and 7.3% for the low-, intermediate-, and high-risk patient groups, respectively (p<0.001).

Conclusions

Our newly proposed HCC-SM GPA successfully predicted survival outcomes.

INTRODUCTION

Although hepatocellular carcinoma (HCC) is a lethal disease, the prognosis of patients with HCC has improved continuously in recent decades, subsequent to the development of diagnostic tools and treatment modalities.^1–3 Consequently, bone metastases of HCC have become a more frequent occurrence.^1,2 Spinal metastasis (SM) occurs in 50% to 75% of cases of bone metastases of HCC and can lead to neurologic deficits and a reduced quality of life.^4–8 Surgery can provide restoration of mechanical instability and emergent decompression,^9,10 while chemotherapy can be used to treat systemically with targeted agent such as sorafenib.^11–14 Radiotherapy (RT) can effectively provide palliation of painful SM in approximately 60% to 97% of patients, with up to 32% of patients experiencing a complete response in terms of pain relief.^4,15,16 Although spinal involvement is thought to indicate a poor prognosis,^5,16 patients with SM exhibit widely variable survival durations, and certain patients have favorable lifespans of up to 2 years.^3,4,15 In our previous report, the follow-up times of patients ranged from 0.5 to 125 months, and 32 of 192 patients (16.7%) survived for longer than 1 year.⁴ These findings suggest the necessity of accurate survival predictions that could be used to identify different prognostic groups and determine the intensity of treatment accordingly.

A graded prognostic assessment (GPA) can be defined as a prognosis-predictive scoring model derived from clinical factors found to affect survival. Following the development of a GPA for brain metastases by the Radiation Therapy Oncology Group,^17,18 similar models have been developed for breast cancer¹⁹ and HCC,²⁰ and several prognosis-predictive scoring models have been used for SM.^21–23 However, an HCC-specific SM GPA has not previously been developed.

Accordingly, the present study aimed to develop a HCC-SM GPA that could be used to classify patients according to risk groups and apply treatment according to prognosis.

MATERIALS AND METHODS

1. Patient population

In our previous study, we reported the clinical outcomes of 192 HCC patients with SM who received RT at Yonsei Cancer Center from April 1992 to February 2012. These patients were defined as the training group, and significant prognostic factors identified through a multivariate analysis were used to develop the HCC-SM GPA. To validate our HCC-SM GPA, we recruited an independent cohort of 63 patients who presented with HCC with SM at two independent hospitals with a shared university affiliation, Yonsei Cancer Center and Gangnam-Severance Hospital (45 and 18 patients, respectively) from September 2011 to March 2016.

2. Evaluation of primary tumor progression and assessment of SM

A controlled primary tumor was defined as a lack of evidence of HCC in the liver on follow-up imaging studies conducted after treatment for HCC.⁴ SM was characterized by multiplicity, a mass-type nature, spinal cord compression, and pathologic fracture due to metastasis.⁴ A mass-type metastasis was defined as a soft tissue mass associated with bone lesion outside of the spine. Spinal cord compression was defined as radiologic tumor involvement of the spinal canal with neurologic symptoms (American Spinal Injury Association [ASIA] impairment scale of A, B, or C).²⁴ Pathologic fracture was defined as a fracture due to a metastasis of HCC.

3. Statistical analysis

Overall survival was measured from the time of RT initiation. The Breslow test, which has been identified as superior for detecting early differences,²⁵ was used to compare the survival outcomes of different risk groups. All statistical analyses were performed using SPSS version 20.0 (IBM Corp., Armonk, NY, USA). All p-values <0.05 were considered statistically significant.

RESULTS

1. Patient characteristics

In the training group, which had a median follow-up period of 4.2 months (range, 0.3 to 124.8 months) and median age of 55.5 years (range, 20 to 82 years), 181 patients (94.3%) were followed until death. The majority of patients in this group were men (157, 81.7%) and had a Child-Pugh class status of A (70.8%). In addition, most patients (54.2%) had an Eastern Cooperative Oncology Group (ECOG) performance status of ≤2.

The validation group had a median follow-up period of 4.3 months (range, 0.3 to 28.8 months) and median age of 60 years (range, 38 to 82 years). In this group, 56 of 63 patients (88.9%) were followed until death. Most of patients were men (93.7%) and had a Child-Pugh class status of A (76.2%) and ECOG performance score of 0–2 (88.9%).

2. GPA for HCC patients with SM

In our previous study, the ECOG performance status, controlled status of primary HCC, extrahepatic metastases other than bone, and biologic equivalent dose (BED) of RT were identified as statistically significant prognostic factors affecting survival (Table 1). Because the BED is a treatment-related factor that cannot be used to predict outcomes prior to treatment, it was not included in our HCC-SM GPA. To construct the HCC-SM GPA, we obtained a prognostic score for each factor using the partial score method,^26,27 wherein each partial score was calculated by dividing the each magnitude of the regression coefficient by the smallest statistically significant regression coefficient and rounding each derived value to the nearest integer or the nearest integer plus 0.5. Finally, these partial scores were summed to calculate a GPA score for each patient. The parameters for which partial scores were derived were the ECOG performance status (0–2, 0 point; 3–4, 1 point), controlled status of primary HCC (controlled, 0 point; uncontrolled, 2 points), and extrahepatic metastases other than bone (no, 0 point; yes, 1 point). Scores of 0 and 4 were considered the best and worst predictive prognostic scores, respectively. Partial scores of the included factors and a definition of the HCC-SM GPA are shown in Table 2. After calculating the HCC-SM GPA by summing the partial scores of each factor, we divided the scores to form three risk groups: score of 0, low-risk group; scores of 1 to 2, intermediate-risk group; and scores of 3 to 4, high-risk group.

Table 1.

Prognostic Factor Analyses for Overall Survival of the Training Group

	Univariate analysis			Multivariate analysis
	No. of patients	MS, mo	p-value*	Coefficient	HR	95% CI	p-value†
Age, yr			0.492	-	-	-	-
≤55	86	4.8
>55	106	3.9
Gender			0.430	-	-	-	-
Male	157	4.5
Female	35	5.3
ECOG performance status			<0.001	0.639	1.895	1.302–2.757	0.001
0–2	104	5.7
3–4	88	2.7
AFP, ng/mL			0.143	-	-	-	-
≤200	98	4.7
>200	94	2.8
Child-Pugh classification			0.025	0.259	1.165	0.693–1.755	0.164
A, B	172	4.5
C	20	2.0
Primary HCC			<0.001	1.279	3.595	2.453–5.268	<0.001
Controlled	127	6.2
Uncontrolled	65	1.9
Interval from diagnosis of primary tumor to spinal metastases, mo			0.966	-	-	-	-
≤9	100	4.2
>9	92	4.0
Baseline BPI score (pain severity)			0.857	-	-	-	-
≤6	114	4.8
>6	78	4.2
Extrahepatic metastases other than bone			0.012	−0.560	0.571	0.391–0.835	0.004
Yes	50	2.8
No	142	5.0
Site of spinal metastasis			0.169	-	-	-	-
Cervical	26	2.5
Thoracic	46	4.8
Lumbar	48	5.7
Sacrum	8	4.5
Combined (2 sites or more)	64	3.7
Multiplicity of spinal metastases			0.112	-	-	-	-
Yes	105	5.0
No	87	3.9
Mass-type metastases			0.577	-	-	-	-
Yes	46	4.7
No	146	4.5
Spinal cord compression (ASIA scale A–C)			0.839	-	-	-	-
Yes (A–C)	25	4.0
No (D, E)	167	4.5
Pathologic fracture			0.003	−0.342	0.710	0.476–1.059	0.093
Yes	47	2.7
No	145	5.0
BED, Gy10			<0.001	−0.624	0.536	0.383–0.751	<0.001
≤38	38	2.4
39–53	132	9.7
>53	22	15.2
Treatment modalities			0.926	-	-	-	-
RT alone	140	3.9
RT+CTx	38	4.0
RT+S±CTx	14	5.3
RT technique			0.110	-	-	-	-
Conventional (2D)	107	3.9
3D-CRT of IMRT	85	4.5
Pain response			0.001	0.308	1.361	0.938–1.973	0.104
CR	41	7.2
Non-CR	151	3.0

Adapted from Choi C, Seong J. Gut Liver 2015;9:94–102.⁴

MS, median survival; HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; AFP, α-fetoprotein; HCC, hepatocellular carcinoma; BPI, brief pain inventory; ASIA, American Spinal Injury Association; BED, biologically effective dose; RT, radiotherapy; CTx, chemotherapy; S, surgery; 2D, 2-dimensional; 3D-CRT, 3-dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; CR, complete pain response.

^*Determined using the log-rank test;

^†Determined using the Cox proportional hazard model.

Table 2.

Definition of HCC-SM GPA

	Magnitude of coefficient	Partial score	GPA
			0	1	2
ECOG performance	0.639	1	0–2	3–4
Primary controlled	1.279	2	Controlled		Uncontrolled
Extrahepatic metastases other than bone	0.571	1	No	Yes

HCC, hepatocellular carcinoma; SM, spinal metastasis; GPA, graded prognostic assessment; ECOG, Eastern Cooperative Oncology Group performance status.

In the training group, overall survival times among all risk groups were significantly different (p<0.001), between low- and intermediate-groups (p=0.001), and between intermediate- and high-risk groups (p=0.002). The median survival periods were 5.9 (95% confidence interval [CI], 4.9 to 6.8; n=101), 3.4 (95% CI, 2.2 to 4.6; n=81), and 1.0 (95% CI, 0.7–1.3; n=10) months for the low-, intermediate-, and high-risk groups, respectively, with corresponding 6-month survival rates of 49.0%, 24.8%, and 10.0%, respectively (Fig. 1).

Fig. 1.

Survival outcomes in the training group according to the graded prognostic assessment for hepatocellular carcinoma patients with spinal metastasis (HCC-SM GPA). The risk groups were defined as follows: low risk group, GPA score 0; intermediate risk group, GPA scores 1 to 2; and high risk group, GPA scores 3 to 4. Overall survival differed among all subgroups (p<0.001), between the low-risk and intermediate-risk groups (p=0.001), and between the intermediate-risk and high-risk groups (p=0.002). RT, radiotherapy.

3. Validation

We applied the HCC-SM GPA to our validation cohort, and observed significant differences in survival times among the risk groups (Fig. 2). The survival outcomes differed significantly among all subgroups (p<0.001), as well as between the low- and intermediate-risk groups (p=0.014) and the intermediate- and high-risk groups (p<0.009). The median survival durations were 13.6 (95% CI, 2.0 to 25.2; n=12), 4.8 (95% CI, 1.9 to 7.6; n=19), and 2.6 (95% CI, 1.5 to 3.7; n=32) months for the low-, intermediate-, and high-risk groups, respectively, with corresponding 6-month survival rates of 91.7%, 47.4%, and 21.8%, respectively. The summarized results are shown in Table 3.

Fig. 2.

Survival outcomes in the validation group according to the graded prognostic assessment for hepatocellular carcinoma patients with spinal metastasis (HCC-SM GPA). The risk groups were defined as follows: low-risk group, GPA score 0; intermediate-risk group, GPA scores 1 to 2; and high-risk group, GPA scores 3 to 4. Overall survival differed among all subgroups (p<0.001), between the low-risk and intermediate-risk groups (p=0.014), and between the intermediate-risk and high-risk groups (p=0.009). RT, radiotherapy.

Table 3.

Survival Results in the Validation Group According to the GPA Score

	GPA score	No.	MS	95% CI	1 yr OS, %	6 mo OS, %	p-value
Low risk	0	12	13.6	2.0–25.2	58.3	91.7		0.014				<0.001
Intermediate risk	1–2	19	4.8	1.9–7.6	17.8	47.4				0.009
High risk	3–4	32	2.6	1.5–3.7	7.3	21.8

GPA, graded prognostic assessment; MS, median survival; CI, confidence interval; OS, overall survival.

As compared to training group, the validation group has more patients with uncontrolled primary HCC (65.1% vs 15.6%, p<0.001) and extrahepatic metastases other than bone (61.9% vs 26.0%, p<0.001). There was no statistically significant difference in patient distribution according to ECOG performance status (p=0.377). The result of survival analysis of the validation group is presented in Table 4.

Table 4.

Prognostic Factor Analysis for Overall Survival of the Validation Group

	Univariate analysis			Multivariate analysis
	No. of patients	MS, mo	p-value*	Coefficient	HR	95% CI	p-value†
Age, yr			0.058	-	-	-	-
≤55	20	3.4
>55	43	5.8
Gender			0.567	-	-	-	-
Male	59	4.8
Female	4	2.0
ECOG performance status			<0.001	2.584	13.244	4.606–38.079	<0.001
0–2	56	5.8
3–4	7	1.4
AFP, ng/mL			<0.001	1.284	3.613	1.873–6.967	<0.001
≤200	32	9.8
>200	31	3.0
Child-Pugh classification			<0.001	2.868	17.610	5.262–58.933	<0.001
A, B	58	4.8
C	5	0.4
Primary HCC			0.004	1.054	2.869	1.425–5.778	0.003
Controlled	22	9.0
Uncontrolled	41	3.4
Interval from diagnosis of primary tumor to spinal metastases, mo			0.692	-	-	-	-
≤12	28	3.7
>12	35	5.8
Baseline BPI score (pain severity)			0.887	-	-	-	-
≤6	40	4.8
>6	20	4.5
Extrahepatic metastases other than bone			<0.001	1.213	3.362	1.676–6.743	0.001
Yes	39	2.7
No	24	9.8
Site of spinal metastasis			0.051	-	-	-	-
Cervical	2	10.5
Thoracic	13	6.4
Lumbar	6	7.3
Sacrum	4	13.8
Combined (2 sites or more)	38	3.7
Multiplicity of spinal metastases			0.013	0.635	1.887	0.976–3.648	0.059
Yes	41	3.7
No	22	8.9
Mass-type metastases			0.200	-	-	-	-
Yes	29	3.7
No	34	5.8
Spinal cord compression (ASIA scale A–C)			0.025	−0.072	0.930	0.424–2.040	0.857
Yes (A–C)	17	3.4
No (D, E)	46	5.8
Pathologic fracture			0.301	-	-	-	-
Yes	22	3.4
No	41	5.2
BED, Gy10			0.010	−0.038	0.963	0.398–2.329	0.932
≤38	29	3.0
39–53	23	7.6
>53	11	8.9
Treatment modalities			0.228	-	-	-	-
RT alone	24	5.8
RT+CTx	27	3.7
RT+S±CTx	12	8.9
RT technique			0.913	-	-	-	-
3D-CRT or conventional 2D	39	4.5
IMRT or tomotherapy	24	4.8
Pain response			0.209	-	-	-	-
CR	13	8.8
Non-CR	47	4.3

MS, median survival; HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; AFP, α-fetoprotein; HCC, hepatocellular carcinoma; BPI, brief pain inventory; ASIA, American Spinal Injury Association; BED, biologically effective dose; RT, radiotherapy; CTx, chemotherapy; S, surgery; 3D-CRT, 3-dimensional conformal radiation therapy; 2D, 2-dimensional; IMRT, intensity-modulated radiation therapy; CR, complete pain response.

^*Determined using the log-rank test;

^†Determined using the Cox proportional hazard model.

DISCUSSION

In the present study, we analyzed a total of 255 HCC patients with SM, including 192 patients who were used to develop the HCC-SM GPA and 63 patients recruited for validation. We found that the risk groups stratified according to our HCC-SM GPA exhibited significant differences in survival outcomes.

Several previous studies have reported various prognostic factors that affect the survival of HCC patients with SM. Chang et al.¹⁵ conducted one of the largest studies, evaluating 102 HCC patients with SM. The median survival interval from SM to death was 3 months, and a good performance status and response to RT were found to significantly affect survival. Goodwin et al.³ performed a meta-analysis of 26 studies that described operative techniques used to treat SM. The authors reported that patients who underwent surgery plus adjuvant therapy, including chemotherapy or RT, displayed a trend toward longer survival when compared to patients treated with either modality alone or subjected to observation. The other clinical prognostic factors were not reported due to low or insufficient statistical strength, because most of the recruited studies were case series. Other studies reported age, Child-Pugh class, Karnofsky performance status scale, and Tomita score (Table 5) as significant factors affecting survival.^14,16,28 However, reports of these prognostic factors were heterogeneous, and the number of studies and number of patients included in each study were relatively small. Therefore, the available information about these previously identified prognostic factors was not sufficient to make treatment decisions.

Table 5.

Reported Series of Clinical Outcomes of Hepatocellular Carcinoma Patients with Spinal Metastasis

Author	Study type	No.	Treatment (%)	OS after SM, mo	OS after treatment for SM	Prognostic factor
Chang et al.15	Retrospective	102	RT (82.3), OP (8.8)	3	-	RT response, ECOG performance
Chang et al.16	Retrospective	27 (SRS group)	SRS (100), OP (10.3)	14	7	Age, Child-Pugh class, KPS
		32 (cRT croup)	cRT (100)		3
Lee et al.14	Retrospective	33	OP (100), RT (36.4)	8.7	6	Tomita score
Sohn et al.28	Retrospective	28 (SRS group)	SRS (100), OP (10.3)	-	8	-
		28 (cRT group)	cRT (100), OP (10.3)		10
Goodwin et al.3	Meta-analysis	26 Articles, 152 patients	OP (84.2), RT (61.8)	10.6	-	Multimodal treatment

OS, overall survival; SM, spine metastasis; RT, radiotherapy; OP, operation; ECOG, Eastern Cooperative Oncology Group performance status; SRS, stereotactic radiosurgery; KPS, Karnofsky Performance Status scale; cRT, conventional RT.

Previously, other authors attempted to stratify the risks of patients with SM and suggested treatment strategies. For example, the Tomita and Tokuhashi scoring systems, which were developed by orthopedic surgeons, are popular models used to predict the prognosis of patients with SM from various cancers.^21,22 The Tomita system includes prognostic parameters of the primary tumor site, visceral metastases, and multiplicity of bone metastasis, whereas the Tokuhashi system incorporates the performance status, number of non-spinal bone metastases, major organ metastasis, primary tumor site, and degree of palsy.²⁹ However, these systems are not easily applied to HCC patients with SM, as survival of HCC patients is largely affected by the primary cancer control status. Furthermore, those systems recommend treatment strategies that mainly focus on spinal surgery, rather than other modalities such as RT or primary cancer treatment.

As noted above, the GPA was originally developed as a prognostic index and quantitative evaluation tool to help clinicians make treatment decisions regarding patients with brain metastases. The GPA has been widely implemented because of its comprehensive nature, ease of use, and good ability to predict prognosis.^17,18 Since the original GPA was developed for brain metastases regardless of any primary cancer, is also not easily applied to HCC. Thus disease specific HCC-GPA was developed and has been clinically useful.²⁰ A similar HCC-specific GPA is needed for patients with SM. Our HCC-SM GPA incorporated three important and well-known prognostic factors: ECOG performance status, primary HCC control status, and extrahepatic metastases other than bone. Furthermore, the HCC-SM GPA was based on a relatively large number of patients and was designed for simplicity and ease of use.

Use of the HCC-SM GPA for patient stratification will allow physicians to apply tailored treatment options according to an individual patient’s life expectancy. The low-risk group, characterized by a favorable performance status and limited extent of non-spinal disease, had a median survival of 13.6 months and 1-year survival rate of 58.3%. This group might accordingly be offered an active therapeutic approach that includes local treatments such as surgery or stereotactic body radiotherapy,^14,30–32 which could ameliorate pain or neurologic symptoms and consequently enhance quality of life, and might even yield a near-cure of oligometastases.^33–36 The intermediate-risk group, which had a median survival of 4.8 months and a 6-month survival rate of 47.4%, encompasses various clinical conditions, and patients in this group should be treated on an individual basis with consideration of their performance status and extent of metastases. The high-risk group, characterized by uncontrolled primary HCC with a poor performance status or a nonspinal metastatic burden, had a median survival duration of only 2.6 months and a 6-month survival rate of 21.8%. For this group, supportive and hospice care would be the best option, thus allowing patients to avoid unnecessary physical or economic burdens from medical treatment.

Beyond treatment strategy decisions, our HCC-SM GPA could also be applied to clinical trial design; for example, researchers could categorize patients according to predicted survival and therefore balance the assortment of patients into individual groups. Furthermore, this tool would be useful for comparing the results of different studies.

Our study had several limitations. First, the number of patients in the validation cohort was relatively small, and approximately half of the patients were classified as being at high risk, whereas only 12 were classified as being at low risk. Therefore, further verification may be needed. Second, our study included only patients who received RT of the spine. The exclusion of patients whose conditions were deemed insufficient for RT or who did not receive RT because of personal or physicians’ preferences might have introduced bias.

In conclusion, the HCC-SM GPA might facilitate the selection of patients who are candidates for active local treatment, and could identify high-risk patients who would benefit from best supportive care. To the best of our knowledge, the HCC-SM GPA, which includes prognostic factors identified in a relatively large, disease-specific study, is the first HCC-specific prognostic model for SM. Further validation and utilization in various patient groups are warranted to establish its efficacy.