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. 1990 Nov;87(21):8341–8344. doi: 10.1073/pnas.87.21.8341

Organ-specific and systemic autoimmune diseases originate from defects in hematopoietic stem cells.

S Ikehara 1, M Kawamura 1, F Takao 1, M Inaba 1, R Yasumizu 1, S Than 1, H Hisha 1, K Sugiura 1, Y Koide 1, T O Yoshida 1, et al.
PMCID: PMC54951  PMID: 2236044

Abstract

Transplantation of bone marrow cells from nonobese diabetic (NOD) mice, a model for type 1 diabetes mellitus, to C3H/HeN mice, which express I-E alpha molecules and have aspartic acid at residue 57 of the I-A beta chain, induced insulitis followed by overt diabetes in the recipient C3H/HeN mice more than 40 weeks after bone marrow transplantation. When cyclosporin A, which perturbs T-cell functions, was injected intraperitoneally into [NOD----C3H/HeN] chimeric mice daily for 1 month, the chimeric mice developed insulitis and overt diabetes within 20 weeks following bone marrow transplantation. Transplantation of bone marrow cells from (NZW x BXSB)F1 mice, which develop lupus nephritis, myocardial infarction, and idiopathic thrombocytopenic purpura, into C3H/HeN or C57BL/6J mice induced in the recipient strains both lupus nephritis and idiopathic thrombocytopenic purpura more than 3 months after transplantation. Transplantation of a stem-cell-enriched population from (NZW x BXSB)F1 mice into normal mice also induced autoimmune disease in the recipients. These results indicate that both systemic autoimmune disease and organ-specific autoimmune disease originate from defects that reside within the stem cells; the thymus and environmental factors such as sex hormones appear to act only as accelerating factors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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