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. 1990 Nov;87(21):8457–8461. doi: 10.1073/pnas.87.21.8457

Cell position and developmental fate in leech embryogenesis.

G P Keleher 1, G S Stent 1
PMCID: PMC54975  PMID: 2236055

Abstract

The o and p blast cell bandlets of the leech Theromyzon rude, which normally produce two different sets of identifiable cells designated the "O" and "P" fates, respectively, form an equivalence group: in embryos experimentally deprived of their p bandlet, the blast cells of the adjacent o bandlet may "transfate" and take on the P fate. Loss of the p bandlet is not, however, a sufficient condition for transfating of the o bandlet. Rather, loss of the p bandlet allows the o bandlet to shift into ectopic positions, and it is the ultimate position of the o bandlet that mandates which fate--O or P--the blast cells will take on. Therefore, the choice of the pluripotent o blast cells to follow either the O or P developmental pathway depends on their perception of positional cues provided by cells outside the equivalence group rather than on a direct interaction with p blast cell equivalence group members.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blair S. S. Blastomere ablation and the developmental origin of identified monoamine-containing neurons in the leech. Dev Biol. 1983 Jan;95(1):65–72. doi: 10.1016/0012-1606(83)90007-6. [DOI] [PubMed] [Google Scholar]
  2. Blair S. S., Weisblat D. A. Ectodermal interactions during neurogenesis in the glossiphoniid leech Helobdella triserialis. Dev Biol. 1982 May;91(1):64–72. doi: 10.1016/0012-1606(82)90008-2. [DOI] [PubMed] [Google Scholar]
  3. Doe C. Q., Goodman C. S. Early events in insect neurogenesis. I. Development and segmental differences in the pattern of neuronal precursor cells. Dev Biol. 1985 Sep;111(1):193–205. doi: 10.1016/0012-1606(85)90445-2. [DOI] [PubMed] [Google Scholar]
  4. Doe C. Q., Goodman C. S. Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells. Dev Biol. 1985 Sep;111(1):206–219. doi: 10.1016/0012-1606(85)90446-4. [DOI] [PubMed] [Google Scholar]
  5. Fernández J. Embryonic development of the glossiphoniid leech Theromyzon rude: characterization of developmental stages. Dev Biol. 1980 May;76(2):245–262. doi: 10.1016/0012-1606(80)90377-2. [DOI] [PubMed] [Google Scholar]
  6. Gimlich R. L., Braun J. Improved fluorescent compounds for tracing cell lineage. Dev Biol. 1985 Jun;109(2):509–514. doi: 10.1016/0012-1606(85)90476-2. [DOI] [PubMed] [Google Scholar]
  7. Ho R. K., Weisblat D. A. A provisional epithelium in leech embryo: cellular origins and influence on a developmental equivalence group. Dev Biol. 1987 Apr;120(2):520–534. doi: 10.1016/0012-1606(87)90255-7. [DOI] [PubMed] [Google Scholar]
  8. Kimble J. Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev Biol. 1981 Oct 30;87(2):286–300. doi: 10.1016/0012-1606(81)90152-4. [DOI] [PubMed] [Google Scholar]
  9. Kuwada J. Y., Goodman C. S. Neuronal determination during embryonic development of the grasshopper nervous system. Dev Biol. 1985 Jul;110(1):114–126. doi: 10.1016/0012-1606(85)90069-7. [DOI] [PubMed] [Google Scholar]
  10. Shankland M. Differentiation of the O and P cell lines in the embryo of the leech. II. Genealogical relationship of descendant pattern elements in alternative developmental pathways. Dev Biol. 1987 Sep;123(1):97–107. doi: 10.1016/0012-1606(87)90431-3. [DOI] [PubMed] [Google Scholar]
  11. Shankland M. Differentiation of the O and p cell lines in the embryo of the leech. I. Sequential commitment of blast cell sublineages. Dev Biol. 1987 Sep;123(1):85–96. doi: 10.1016/0012-1606(87)90430-1. [DOI] [PubMed] [Google Scholar]
  12. Shankland M., Weisblat D. A. Stepwise commitment of blast cell fates during the positional specification of the O and P cell lines in the leech embryo. Dev Biol. 1984 Dec;106(2):326–342. doi: 10.1016/0012-1606(84)90231-8. [DOI] [PubMed] [Google Scholar]
  13. Stent G. S. The role of cell lineage in development. Philos Trans R Soc Lond B Biol Sci. 1985 Dec 17;312(1153):3–19. doi: 10.1098/rstb.1985.0174. [DOI] [PubMed] [Google Scholar]
  14. Sternberg P. W., Horvitz H. R. The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell. 1989 Aug 25;58(4):679–693. doi: 10.1016/0092-8674(89)90103-7. [DOI] [PubMed] [Google Scholar]
  15. Sternberg P. W. Lateral inhibition during vulval induction in Caenorhabditis elegans. Nature. 1988 Oct 6;335(6190):551–554. doi: 10.1038/335551a0. [DOI] [PubMed] [Google Scholar]
  16. Stuart D. K., Blair S. S., Weisblat D. A. Cell lineage, cell death, and the developmental origin of identified serotonin- and dopamine-containing neurons in the leech. J Neurosci. 1987 Apr;7(4):1107–1122. doi: 10.1523/JNEUROSCI.07-04-01107.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stuart D. K., Torrence S. A., Law M. I. Leech neurogenesis. I. Positional commitment of neural precursor cells. Dev Biol. 1989 Nov;136(1):17–39. doi: 10.1016/0012-1606(89)90128-0. [DOI] [PubMed] [Google Scholar]
  18. Sulston J. E., Horvitz H. R. Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Dev Biol. 1981 Feb;82(1):41–55. doi: 10.1016/0012-1606(81)90427-9. [DOI] [PubMed] [Google Scholar]
  19. Sulston J. E., White J. G. Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans. Dev Biol. 1980 Aug;78(2):577–597. doi: 10.1016/0012-1606(80)90353-x. [DOI] [PubMed] [Google Scholar]
  20. Torrence S. A., Law M. I., Stuart D. K. Leech neurogenesis. II. Mesodermal control of neuronal patterns. Dev Biol. 1989 Nov;136(1):40–60. doi: 10.1016/0012-1606(89)90129-2. [DOI] [PubMed] [Google Scholar]
  21. Weisblat D. A., Blair S. S. Developmental interdeterminacy in embryos of the leech Helobdella triserialis. Dev Biol. 1984 Feb;101(2):326–335. doi: 10.1016/0012-1606(84)90146-5. [DOI] [PubMed] [Google Scholar]
  22. Weisblat D. A., Zackson S. L., Blair S. S., Young J. D. Cell lineage analysis by intracellular injection of fluorescent tracers. Science. 1980 Sep 26;209(4464):1538–1541. doi: 10.1126/science.6159680. [DOI] [PubMed] [Google Scholar]
  23. Zackson S. L. Cell lineage, cell-cell interaction, and segment formation in the ectoderm of a glossiphoniid leech embryo. Dev Biol. 1984 Jul;104(1):143–160. doi: 10.1016/0012-1606(84)90044-7. [DOI] [PubMed] [Google Scholar]

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