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. 1990 Nov;87(21):8670–8674. doi: 10.1073/pnas.87.21.8670

Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes.

Y Yamaguchi-Iwai 1, M Satake 1, Y Murakami 1, M Sakai 1, M Muramatsu 1, Y Ito 1
PMCID: PMC55019  PMID: 2122465

Abstract

The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.

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