Table 1.
Outcome | Relative risk reduction | Source |
---|---|---|
Retinopathy * | 29% per 0.9% ↓ A1c | UKPDS27 |
Neuropathy † | 19% per 0.9% ↓ A1c | UKPDS27 |
Microalbuminuria‡ | 33% per 0.9% ↓ A1c | UKPDS27 |
Non-fatal myocardial infarction | 15% per 1.0% ↓ A1c | Boussageon et al.31 |
Surrogate outcome defined as one microaneurysm or more in one eye or worse retinopathy, and progression of retinopathy as a two-step change in Early Treatment of Diabetic Retinopathy Study grade
Surrogate outcome defined as loss of both ankle or both knee reflexes, or mean biothesiometer reading from both toes > 25 volts
Surrogate outcome defined as urinary albumin concentration greater than 50 mg/L