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. 2017 Apr 8;8(24):38084–38098. doi: 10.18632/oncotarget.16970

Figure 5. BEZ235 treatment suppresses FOXO1 and S6 phosphorylation in murine retinoblastoma.

Figure 5

Vehicle or BEZ235 was administered daily to CHX-Cre+; Rb1fl/fl; p107−/−; Ptenfl/fl pups on post-natal days two through six, and retinae were harvested at day seven for immunoblot analysis using the listed antisera specific to p-FOXO1 (Ser256), FOXO1, p-AKT (Ser473), AKT, p-S6 (Ser235/236), S6, and ACTIN. A, B, & C are independent replicates from separately gavaged animals.