Table 1. p-AKT staining intensity correlates with Ki-67⁺ and p-FOXO1⁺ tumor staining.

A		High Ki-67	Low Ki-67	Row Totals
	High p-AKT	11	8	19
	Low p-AKT	0	8	8
	Column Totals	11	16	p = 0.008
B		High p-FOXO1	Low p-FOXO1	Row Totals
	High p-AKT	6	0	6
	Low p-AKT	5	16	21
	Column Totals	11	16	p=0.002

The relative staining intensity of p-Akt, Ki-67, p-FoxO1, and p-S6 was scored for each individual retinoblastoma. Comparisons between p-AKT and Ki-67 (A) or p-AKT and pFOXO1 (B) were converted to a 2 × 2 contingency tables. A. Tumors were separated based on intensity scores of p-AKT >= 2 (High) or p-AKT < 2 (Low) and Ki-67 >= 3 (High) or Ki-67 < 3 (Low). B. Tumors were separated based on intensity scores of p-AKT >= 3 (High) or p-AKT < 3 (Low) and pFOXO1 = 4 (High) or pFOXO1 <= 4 (Low). Total numbers of tumors in each row are displayed. Fisher's exact test was used to calculate two-tailed P-values for the contingency table comparisons.