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. 2017 Mar 15;8(24):38294–38308. doi: 10.18632/oncotarget.16203

Figure 4. ATM signaling regulated by chemotherapy drugs.

Figure 4

(A) Results from three cell lines, HCC1937, HCC1806 and HCC38, treated with 6.4 μM docetaxel (DTX), 4 μM doxorubicin (DXR) or 5 μM STAT3 inhibitor VII. Levels of phospho-ATM, -NDRG2 and -STAT3 showed congruent changes following a similar trend: p-NDRG2 and p-STAT3 were increased when p-ATM was upregulated; p-NDRG2 and p-STAT3 were decreased when p-ATM was suppressed. (B) Gene microarray data show that expression of genes in the ATM pathway was dramatically reduced after 6 h of 4 μM docetaxel treatment. The genes changed ≥ 2 folds and P < 0.05.