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. 2017 Mar 17;8(24):38351–38366. doi: 10.18632/oncotarget.16323

Figure 10. Intestinal CXCL12 expression and carcinoma development in control and VPA-treated APCΔ14/+ mice.

Figure 10

(A) Quantitative evaluation of the number of carcinomas in the entire intestinal tract of control and VPA-treated APCΔ14/+ mice. The APCΔ14/+ mice were intraperitoneally injected with PBS (n = 6) or VPA (n = 5; 500 mg/kg/day) for 30 days. Mann-Whitney parametric test, **p < 0.001. (B–D) Immuno-histochemical CXCL12 expression in the normal colon mucosa of control APCΔ14/+ mice (PBS treated, (B) in a VPA-untreated tumor of an APCΔ14/+ mouse (C) and in the colon of APCΔ14/+ mice treated with 500 mg/kg VPA for 30 days (D).