Table 3. The frequencies of PD-1 rs10204525 T>C, rs36084323 T>C, rs7421861 A>G and rs2227982 A>G polymorphisms in esophagogastric junction adenocarcinoma patients and controls.
| Genotype | Overall EGJA case (n = 1,063) | Overall Controls (n = 1,677) | ||
|---|---|---|---|---|
| n | % | n | % | |
| rs36084323 T>C | ||||
| TT | 282 | 27.09 | 444 | 26.52 |
| TC | 521 | 50.05 | 800 | 47.79 |
| CC | 238 | 22.86 | 430 | 25.69 |
| CT+CC | 759 | 72.91 | 1,230 | 73.48 |
| TT+CT | 803 | 77.14 | 1,244 | 74.31 |
| C allele | 997 | 47.89 | 1,660 | 49.58 |
| rs10204525 T>C | ||||
| TT | 544 | 52.36 | 870 | 51.97 |
| TC | 397 | 38.21 | 672 | 40.14 |
| CC | 98 | 9.43 | 132 | 7.89 |
| TC+CC | 495 | 47.64 | 804 | 48.03 |
| TT+TC | 941 | 90.57 | 1,542 | 92.11 |
| C allele | 593 | 28.54 | 936 | 27.96 |
| rs7421861 A>G | ||||
| AA | 642 | 61.67 | 1,166 | 69.65 |
| AG | 358 | 34.39 | 454 | 27.12 |
| GG | 41 | 3.94 | 54 | 3.23 |
| AG+GG | 399 | 38.33 | 508 | 30.35 |
| AA+AG | 1,000 | 96.06 | 1,620 | 96.77 |
| G allele | 440 | 21.13 | 562 | 16.79 |
| rs2227982 A>G | ||||
| AA | 272 | 26.13 | 442 | 26.40 |
| GA | 549 | 52.74 | 816 | 48.75 |
| GG | 220 | 21.13 | 416 | 24.85 |
| GG+GA | 769 | 73.87 | 1,232 | 73.60 |
| GA+AA | 821 | 78.87 | 1,258 | 75.15 |
| G allele | 989 | 47.50 | 1,648 | 49.22 |