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. 2017 Apr 12;8(24):39460–39475. doi: 10.18632/oncotarget.17063

Figure 2. DNA damage foci form rapidly after SINE treatment.

Figure 2

(A) HT-1080 cells were treated with DMSO (mock) or 1μM selinexor for 2, 4, 8, 16, or 24 hours (h). Cells were fixed and stained for γH2A.X (red) and DNA (blue). (B) Mean fold increase in cells with γH2A.X foci over mock treated cells for each time point was scored. Error bars are the SEM from three replicate experiments, at least 100 cells scored in each. A Student's t-test was performed comparing time points to mock treated. *** is p<0.001, ** is p<0.01 and * is p<0.05. Scale bar = 10μm for all panels.