Table 1. Characteristics of included studies that contributed to associations between rs144848 and cancer risk.

Study [ref] per SNP	Year	Race/ethnicity	Sourcea	Cases				Controls				Allele frequencies		NOS assessment	Cancer type
				Total	NN	NH	HH	Total	NN	NH	HH	Casesb	Controlsb
Healey et al. [12]	2000	Caucasian	PB	234	116	99	19	266	138	115	13	0.71	0.73	7	Breast
Healey et al. [12]	2000	Caucasian	PB	1667	858	664	145	1201	631	493	77	0.71	0.73	7	Breast
Healey et al. [12]	2000	Caucasian	PB	450	236	180	34	228	124	94	10	0.72	0.75	7	Breast
Healey et al. [12]	2000	Caucasian	PB	659	325	285	49	866	433	373	60	0.71	0.72	7	Breast
Healey et al. [12]	2000	Caucasian	PB	449	270	154	25	453	277	152	24	0.77	0.78	7	Breast
Spurdle et al. [45]	2002	Caucasian	PB	1397	720	548	129	775	417	308	50	0.71	0.74	7	Breast
Ishitobi et al. [22]	2003	Asian	HB	149	97	47	5	144	85	56	3	0.81	0.78	7	Breast
Menzel et al. [24]	2004	Caucasian	PB	211	104	91	16	912	482	361	69	0.71	0.73	7	Breast
Menzel et al. [24]	2004	Caucasian	PB	94	53	35	6	152	84	57	11	0.75	0.74	7	Breast
Cox et al. [44]	2005	Caucasian	Nested	1285	695	501	89	1660	884	647	129	0.74	0.73	7	Breast
Millikan et al. [25]	2005	African	PB	762	564	183	15	675	510	153	12	0.86	0.87	7	Breast
Millikan et al. [25]	2005	Caucasian	PB	1265	662	521	82	1135	579	467	89	0.73	0.72	7	Breast
Garcia-Closas et al. [21]	2006	Caucasian	PB	3161	1617	1278	266	2701	1412	1057	232	0.71	0.72	7	Breast
Garcia-Closas et al. [21]	2006	Caucasian	PB	1968	1007	826	135	2276	1239	897	140	0.72	0.74	7	Breast
Johnson et al. [47]	2007	Caucasian	NA	473	233	201	39	2461	1278	993	190	0.71	0.72	6	Breast
Palli et al. [48]	2007	Caucasian	PB	91	48	31	12	261	127	107	27	0.70	0.69	6	Breast
Baynes et al. [46]	2007	Caucasian	PB	4537	2306	1892	339	4339	2182	1824	333	0.72	0.71	7	Breast
Seymour et al. [49]	2008	Caucasian	HB	252	127	111	14	100	50	44	6	0.72	0.72	6	Breast
Dombernowsky et al. [19]	2009	Caucasian	PB	1200	604	503	93	4119	2129	1677	313	0.71	0.72	6	Breast
Juwle et al. [23]	2012	Asian	NA	100	68	28	4	50	39	8	3	0.82	0.86	6	Breast
Hasan et al. [11]	2013	African	HB	100	38	33	29	100	33	32	35	0.55	0.49	6	Breast
Jumaah et al. [50]	2014	African	NA	36	26	10	0	10	10	0	0	0.86	1.00	6	Breast
Auranen et al. [26]	2003	Caucasian	PB	680	355	272	53	1546	819	629	98	0.72	0.73	7	Ovarian
Auranen et al. [26]	2003	Caucasian	PB	441	222	176	43	1097	578	445	74	0.70	0.73	7	Ovarian
Wenham et al. [28]	2003	Caucasian	PB	312	169	128	15	398	227	146	25	0.75	0.75	7	Ovarian
Beesley et al. [32]	2007	Caucasian	PB	492	249	203	40	948	502	383	63	0.71	0.73	8	Ovarian
Beesley et al. [32]	2007	Caucasian	PB	930	460	401	69	825	461	296	68	0.71	0.74	8	Ovarian
Ramus et al. [36]	2008	Mixed	Nested	4174	2196	1655	323	7402	3859	2979	564	0.72	0.72	7	Ovarian
Quaye et al. [37]	2009	Caucasian	PB	1459	779	569	111	2294	1200	925	169	0.73	0.72	7	Ovarian
Shen et al. [30]	2006	Mixed	PB	476	250	191	35	555	301	220	34	0.73	0.74	7	NHLc
Scott et al. [33]	2007	Caucasian	PB	757	387	307	63	676	375	253	48	0.71	0.74	7	NHL
Shen et al. [34]	2007	Caucasian	PB	556	271	236	49	498	246	203	49	0.70	0.70	7	NHL
Hill et al. [16]	2006	Mixed	PB	1116	577	441	98	926	505	361	60	0.71	0.74	7	NHL
Salagovic et al. [39]	2012	Caucasian	HB	107	62	34	11	127	82	40	5	0.74	0.80	7	NHL
Hu et al. [27]	2003	Asian	PB	120	69	39	12	231	126	95	10	0.74	0.75	6	Esophageal
Wu et al. [31]	2006	Caucasian	PB	604	306	246	52	595	332	223	40	0.71	0.75	8	Bladder
Debniak et al. [35]	2008	Caucasian	Nested	627	288	280	59	3819	1994	1580	245	0.68	0.73	6	Melanoma
Agalliu et al. [15]	2010	Caucasian	PB	1269	655	498	116	1243	654	500	89	0.71	0.73	8	Prostate
Agalliu et al. [15]	2010	African	PB	142	104	36	2	79	59	18	2	0.86	0.86	8	Prostate
Kotnis et al. [38]	2012	Asian	HB	109	35	56	18	186	81	70	35	0.58	0.62	7	Multiple

^a Source in control, PB population-based study, HB hospital-based study

^b Major allele frequency

^c non-Hodgkin lymphoma