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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1990 Nov;87(22):8903–8907. doi: 10.1073/pnas.87.22.8903

Alternative Shaker transcripts express either rapidly inactivating or noninactivating K+ channels.

M Stocker 1, W Stühmer 1, R Wittka 1, X Wang 1, R Müller 1, A Ferrus 1, O Pongs 1
PMCID: PMC55068  PMID: 1701056

Abstract

Two members of the Shaker K+ channel family designated ShA2 and ShD2 were characterized in the Xenopus oocyte expression system. The predicted amino acid sequences of ShA2 and ShD2 differ only in the amino terminus, which is located intracellularly according to the present topological model of K+ channels. The differing amino termini have profound effects on the electrophysiological and pharmacological properties of the K+ channel. Most markedly, the nature of the amino terminus determines whether the K+ channel mediates rapidly inactivating or noninactivating K+ currents. It also affects the 4-aminopyridine, tetraethylammonium, and charybdotoxin sensitivities of the K+ channels. These results suggest that the amino terminus of Shaker proteins affects K+ channel structures on both sides of the membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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