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. 1979 Jan;23(1):34–40. doi: 10.1128/iai.23.1.34-40.1979

Correlation between in vivo and in vitro functional tests for activated macrophages.

J M Rhodes, J Bennedsen, S O Larsen, S Riisgaard, J V Spärck
PMCID: PMC550685  PMID: 33898

Abstract

Mice undergoing graft-versus-host reaction, skin grafting, and inoculation with tumor cells were tested for nonspecific resistance by intravenous challenge with Listeria monocytogenes. Peritoneal exudate macrophages from mice treated in a similar manner were tested in vitro for increased degradation of [1-14C]glucose, ability to degrade antigen/antibody complexes, ability to inhibit intracellular growth of listeria, and staining for beta-galactosidase. There was good correlation between in vivo resistance towards L. monocytogenes and in vitro inhibition of intracellular growth. There was also good correlation between increase in beta-galactosidase and in vivo resistance in mice undergoing a graft-versus-host-reaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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