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. 1980 Jan;27(1):6–14. doi: 10.1128/iai.27.1.6-14.1980

Demonstration of specific binding sites for human serum albumin in group C and G streptococci.

E B Myhre, G Kronvall
PMCID: PMC550713  PMID: 6987178

Abstract

A total of 297 bacterial strains belonging to 27 species was tested for quantitative uptake of radiolabeled human serum albumin. Specific binding sites with high affinity for human serum albumin were found exclusively in group C and G streptococci. The albumin binding was found to be a time-dependent, saturable, and displaceable process which obeyed simple kinetic equations. Scatchard analysis revealed that human serum albumin bound to a homogeneous population of receptors with an affinity in the order ot 10(7) liters/mol and that the average bacterial cell carried more than 80,000 binding sites. The albumin receptor is a heat-stable component susceptible to proteolytic digestion. It has a surface localization separate from the receptors for immunolgobulin G, fibrinogen, aggregated beta 2-microglobulin, and haptoglobin. In individual strains, albumin reactivity was also detected independently of these other types of interactions with human proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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