Abstract
The cecal contents of guinea pigs with clindamycin-associated colitis contained a heat-labile toxin. This toxin was lethal for guinea pigs and mice, produced vascular permeability in the skin of rabbits, and was cytotoxic in tissue culture. The lethality in mice, vascular permeability in rabbit skin, and cytotoxicity in tissue culture monolayers were neutralized by Clostridium sordellii antitoxin.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allo M., Silva J., Jr, Fekety R., Rifkin G. D., Waskin H. Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxin. Gastroenterology. 1979 Feb;76(2):351–355. [PubMed] [Google Scholar]
- Arseculeratne S. N., Panabokké R. G., Wijesundera S. The toxins responsible for the lesions of Clostridium sordelli gas gangrene. J Med Microbiol. 1969 Feb;2(1):37–53. doi: 10.1099/00222615-2-1-37. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G., Chang T. W., Gurwith M., Gorbach S. L., Onderdonk A. B. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978 Mar 9;298(10):531–534. doi: 10.1056/NEJM197803092981003. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G., Chang T. W., Onderdonk A. B. Comparison of five regimens for treatment of experimental clindamycin-associated colitis. J Infect Dis. 1978 Jul;138(1):81–86. doi: 10.1093/infdis/138.1.81. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G., Onderdonk A. B., Cisneros R. L. Clindamycin-associated colitis in hamsters: protection with vancomycin. Gastroenterology. 1977 Oct;73(4 Pt 1):772–776. [PubMed] [Google Scholar]
- Bartlett J. G., Onderdonk A. B., Cisneros R. L., Kasper D. L. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. J Infect Dis. 1977 Nov;136(5):701–705. doi: 10.1093/infdis/136.5.701. [DOI] [PubMed] [Google Scholar]
- Chang T. W., Bartlett J. G., Gorbach S. L., Onderdonk A. B. Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients. Infect Immun. 1978 May;20(2):526–529. doi: 10.1128/iai.20.2.526-529.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans D. J., Jr, Evans D. G., Gorbach S. L. Production of vascular permeability factor by enterotoxigenic Escherichia coli isolated from man. Infect Immun. 1973 Nov;8(5):725–730. doi: 10.1128/iai.8.5.725-730.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farrar W. E., Kent T. H., Elliott V. B. Lethal gram-negative bacterial superinfection in Guinea pigs given bacitracin. J Bacteriol. 1966 Aug;92(2):496–501. doi: 10.1128/jb.92.2.496-501.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GRAY J. E., PURMALIS A., FEENSTRA E. S. ANIMAL TOXICITY STUDIES OF A NEW ANTIBIOTIC, LINCOMYCIN. Toxicol Appl Pharmacol. 1964 Jul;6:476–496. doi: 10.1016/s0041-008x(64)80014-4. [DOI] [PubMed] [Google Scholar]
- Knoop F. C. Clindamycin-associated enterocolitis in guinea pigs: evidence for a bacterial toxin. Infect Immun. 1979 Jan;23(1):31–33. doi: 10.1128/iai.23.1.31-33.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- LaMont J. T., Sonnenblick E. B., Rothman S. Role of clostridial toxin in the pathogenesis of clindamycin colitis in rabbits. Gastroenterology. 1979 Feb;76(2):356–361. [PubMed] [Google Scholar]
- Larson H. E., Price A. B., Honour P., Borriello S. P. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet. 1978 May 20;1(8073):1063–1066. doi: 10.1016/s0140-6736(78)90912-1. [DOI] [PubMed] [Google Scholar]
- Larson H. E., Price A. B. Pseudomembranous colitis: Presence of clostridial toxin. Lancet. 1977 Dec 24;2(8052-8053):1312–1314. doi: 10.1016/s0140-6736(77)90363-4. [DOI] [PubMed] [Google Scholar]
- Rifkin G. D., Fekety F. R., Silva J., Jr Antibiotic-induced colitis implication of a toxin neutralised by Clostridium sordellii antitoxin. Lancet. 1977 Nov 26;2(8048):1103–1106. doi: 10.1016/s0140-6736(77)90547-5. [DOI] [PubMed] [Google Scholar]
- Rifkin G. D., Silva J., Jr, Fekety R. Gastrointestinal and systemic toxicity of fecal extracts from hamsters with clindamycin-induced colitis. Gastroenterology. 1978 Jan;74(1):52–57. [PubMed] [Google Scholar]