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. 2017 Apr 21;20(4):450–463. doi: 10.1007/s11102-017-0805-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Pituitary corticotroph adenomas. a Ultrastructural features of densely granulated corticotroph adenoma: well-developed organelles, numerous, variable in shape, and electron dense secretory granules. Original magnification ×7400. b Electron microscopy of sparsely granulated corticotroph adenoma: small and scanty secretory granules. Original magnification ×9700. c H&E staining of Crooke’s cell adenoma (×200). d Ultrastructural features of Crooke’s cell adenoma: excessive accumulation of perinuclear cytokeratin filaments. Original magnification ×9700