Table 1.
MIC90 values of TXY536 and PC against various Gram-positive bacteriaa
| Organism | Strain | MIC90 (µg/mL) | |
|---|---|---|---|
|
| |||
| PC | TXY536 | ||
| S. aureus (MSSA) | 8325-4 | 0.25 | 0.5 |
| S. aureus (MSSA) | ATCC 19636 | 0.5 | 0.5 |
| S. aureus (MSSA) | ATCC 29213 | 1.0 | 1.0 |
| S. aureus (MSSA) | ATCC49951 | 0.5 | 1.0 |
| S. aureus (MRSA) | ATCC 33591 | 0.5 | 0.5 |
| S. aureus (MRSA) | ATCC 43300 | 0.5 | 1.0 |
| B. subtilis | 168 | 0.5 | 1.0 |
| E. faecalis (VSE) | ATCC 19433 | 32.0 | 32.0 |
| E. faecalis (VRE) | ATCC 51575 | 32.0 | 64.0 |
| E. faecium (VSE) | ATCC 19434 | 64.0 | >64.0 |
| S. pyogenes (GAS) | ATCC 19615 | >64.0 | >64.0 |
| S. agalactiae (GBS) | ATCC 12386 | >64.0 | >64.0 |
| S. pneumoniae | ATCC 49619 | >64.0 | 64.0 |
a
MIC90 values reflect the lowest compound concentrations at which growth was ≥90% inhibited.