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. 1980 May;28(2):325–330. doi: 10.1128/iai.28.2.325-330.1980

Effects of immunization and anticoagulation on the development of experimental Escherichia coli endocarditis.

L Thörig, J Thompson, R van Furth
PMCID: PMC550937  PMID: 6995305

Abstract

The effects of immunization and anticoagulation in experimental Escherichia coli endocarditis were studied. Immunization of rabbits with E. coli resulted in the development of specific agglutinating and opsonic activity of the serum, but not in bactericidal activity. These antibody activities also developed in nonimmunized rabbits during the course of bactericidal endocarditis. Immune serum promoted phagocytosis in vitro but did not enhance intracellular killing of E. coli by elicited rabbit peritoneal macrophages. The presence of specific antibodies in rabbits after immunization had no effect on the induction or course of E. coli infection of endocardial vegetations. Anticoagulation was found to affect the induction of the infection. In anticoagulated rabbits, larger bacterial inocula were needed to induce an infection, but in animals with bacterial endocarditis the number of bacteria in the vegetations did not differ significantly from that of the control animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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