Abstract
The induction of delayed-type hypersensitivity to Mycobacterium bovis BCG was specifically inhibited by suppressor T cells in C3H/He, a strain of mice which is a low responder to BCG. The existence of these suppressor cells was confirmed by an adoptive transfer of spleen cells of BCG-injected mice into cyclophosphamide-treated recipients. The suppressor cells appeared in the spleens of the mice 2 to 7 days after intravenous BCG injection. They were sensitive to anti-theta serum and complement and did not adhere to Sephadex G-10. A pretreatment of the mice with cyclophosphamide eliminated the suppression of delayed-type hypersensitivity. These suppressor cells effectively inhibited the induction of delayed-type hypersensitivity to BCG, but showed only weak effect on the expression of it.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Coulis P. A., Lewert R. M., Fitch F. W. [Splenic suppressor cells and cell-mediated cytotoxicity in murine schistosomiasis]. J Immunol. 1978 Jan;120(1):58–60. [PubMed] [Google Scholar]
- Erb P., Meier B., Feldmann M. Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product? J Immunol. 1979 May;122(5):1916–1919. [PubMed] [Google Scholar]
- Gentner G. J., Adelmann B. C. Specific suppression of delayed hypersensitivity skin reactions to collagen in guinea-pigs after immunization with collagen and Freund's incomplete adjuvant. Immunology. 1976 Jul;31(1):87–94. [PMC free article] [PubMed] [Google Scholar]
- Ha T. Y., Waksman B. H. Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients. J Immunol. 1973 May;110(5):1290–1299. [PubMed] [Google Scholar]
- Kirchner H., Holden H. T., Herberman Splenic suppressor macrophages induced in mice by injection of Corynebacterium parvum. J Immunol. 1975 Nov;115(5):1212–1216. [PubMed] [Google Scholar]
- Klimpel G. R., Henney C. S. BCG-induced suppressor cells. I. Demonstration of a macrophage-like suppressor cell that inhibits cytotoxic T cell generation in vitro. J Immunol. 1978 Feb;120(2):563–569. [PubMed] [Google Scholar]
- Lagrange P. H., Mackaness G. B., Miller T. E. Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide. J Exp Med. 1974 Jun 1;139(6):1529–1539. doi: 10.1084/jem.139.6.1529. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ly I. A., Mishell R. I. Separation of mouse spleen cells by passage through columns of sephadex G-10. J Immunol Methods. 1974 Aug;5(3):239–247. doi: 10.1016/0022-1759(74)90108-2. [DOI] [PubMed] [Google Scholar]
- Nakamura R. M., Tokunaga T. Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice. Infect Immun. 1978 Dec;22(3):657–664. doi: 10.1128/iai.22.3.657-664.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nakamura R. M., Tokunaga T., Yamamoto S. Difference in antigen-presenting ability of macrophages between high- and low-responder mice in delayed-type hypersensitivity to Mycobacterium bovis BCG. Infect Immun. 1980 Jan;27(1):268–270. doi: 10.1128/iai.27.1.268-270.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Novogrodsky A., Rubin A. L., Stenzel K. H. Selective suppression by adherent cells, prostaglandin, and cyclic AMP analogues of blastogenesis induced by different mitogens. J Immunol. 1979 Jan;122(1):1–7. [PubMed] [Google Scholar]
- Phanupak P., Moorhead J. W., Claman H. N. Tolerance and contact sensitivity to DNFB in mice. 3. Transfer of tolerance with "suppressor T cells". J Immunol. 1974 Oct;113(4):1230–1236. [PubMed] [Google Scholar]
- Polak L. Studies on the role of suppressor cells in specific unresponsiveness to DNCB. Immunology. 1976 Sep;31(3):425–432. [PMC free article] [PubMed] [Google Scholar]
- Ramos C., Schädtler-Siwon I., Ortiz-Ortiz L. Suppressor cells present in the spleens of Trypanosoma cruzi-infected mice. J Immunol. 1979 Apr;122(4):1243–1247. [PubMed] [Google Scholar]
- Röllinghoff M., Starzinski-Powitz A., Pfizenmaier K., Wagner H. Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes. J Exp Med. 1977 Feb 1;145(2):455–459. doi: 10.1084/jem.145.2.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sy M. S., Miller S. D., Claman H. N. Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide. J Immunol. 1977 Jul;119(1):240–244. [PubMed] [Google Scholar]
- Sy M. S., Miller S. D., Kowach H. B., Claman H. N. A splenic requirement for the generation of suppressor T cells. J Immunol. 1977 Dec;119(6):2095–2099. [PubMed] [Google Scholar]
- Zembala M., Asherson G. L. Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice. Nature. 1973 Jul 27;244(5413):227–228. doi: 10.1038/244227a0. [DOI] [PubMed] [Google Scholar]