Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1980 May;28(2):393–397. doi: 10.1128/iai.28.2.393-397.1980

Identification of staphylococcal Panton-Valentine leukocidin as a potent dermonecrotic toxin.

P D Ward, W H Turner
PMCID: PMC550947  PMID: 7399669

Abstract

The Panton-Valentine leukocidin of Staphylococcus aureus was shown to exhibit a potent dermonecrotic effect when injected intradermally into rabbits. This effect could be abrogated by immunizing animals with the F component or both components, but immunization with the S component appeared to exacerbate certain of the intradermal responses.

Full text

PDF
393

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adlam C., Thorley C. M., Ward P. D., Collins M., Lucken R. N., Knight P. A. Natural and experimental staphylococcal mastitis in rabbits. J Comp Pathol. 1976 Oct;86(4):581–593. doi: 10.1016/0021-9975(76)90067-0. [DOI] [PubMed] [Google Scholar]
  2. Agarwal D. S. Subcutaneous staphylococcal infection in mice. I. The role of cotton-dust in enhancing infection. Br J Exp Pathol. 1967 Aug;48(4):436–449. [PMC free article] [PubMed] [Google Scholar]
  3. BROWN R. W., SCHERER R. K. A study of the necrotizing action of staphylococcic alpha toxin. Am J Vet Res. 1958 Apr;19(71):354–362. [PubMed] [Google Scholar]
  4. COLBECK J. C. Studies in hospital infections. I. Can Serv Med J. 1956 Jul-Aug;12(7):563–580. [PubMed] [Google Scholar]
  5. GLADSTONE G. P., MUDD S., HOCHSTEIN H. D., LENHART N. A. The assay of anti-staphylococcal leucocidal components (F and S) in human serum. Br J Exp Pathol. 1962 Jun;43:295–312. [PMC free article] [PubMed] [Google Scholar]
  6. Kreger A. S., Kim K. S., Zaboretzky F., Bernheimer A. W. Purification and properties of staphylococcal delta hemolysin. Infect Immun. 1971 Mar;3(3):449–465. doi: 10.1128/iai.3.3.449-465.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Omenn G. S., Friedman J. Isolation of mutants of Staphylococcus aureus lacking extracellular nuclease activity. J Bacteriol. 1970 Mar;101(3):921–924. doi: 10.1128/jb.101.3.921-924.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SIERRA G. A simple method for the detection of lipolytic activity of micro-organisms and some observations on the influence of the contact between cells and fatty substrates. Antonie Van Leeuwenhoek. 1957;23(1):15–22. doi: 10.1007/BF02545855. [DOI] [PubMed] [Google Scholar]
  9. WOODIN A. M. Assay of the two components of staphylococcal leucocidin and their antibodies. J Pathol Bacteriol. 1961 Jan;81:63–68. doi: 10.1002/path.1700810108. [DOI] [PubMed] [Google Scholar]
  10. Wadström T., Möllby R. Studies on extracellular proteins from Staphylococcus aureus. VII. Studies on -haemolysin. Biochim Biophys Acta. 1971 Jul 21;242(1):308–320. doi: 10.1016/0005-2744(71)90110-0. [DOI] [PubMed] [Google Scholar]
  11. Ward P. D., Adlam C., McCartney A. C., Arbuthnott J. P., Thorley C. M. A histopathological study of the effects of highly purified staphlococcal alpha and beta toxins on the lactating mammary gland and skin of the rabbit. J Comp Pathol. 1979 Apr;89(2):169–177. doi: 10.1016/0021-9975(79)90056-2. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES