Abstract
We succeeded in enumerating interferon-producing cells induced by allogeneic stimulation, and proved that they were indeed T lymphocytes. The peak level of these cells in spleen was attained on day 5 after immunication, was maintained for about 2 days, and declined thereafter. Titers of interferon produced in vitro by sensitized spleen cells were maximum on day 7. This suggests that the maturation of immune interferon-producing cells follows cell proliferation after antigen stimulation.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bloom B. R., Jimenez L., Marcus P. I. A plaque assay for enumerating antigen-sensitive cells in delayed-type hypersensitivity. J Exp Med. 1970 Jul 1;132(1):16–30. doi: 10.1084/jem.132.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ito Y., Nishiyama Y., Shimokata K., Takeyama H., Kunii A. Immune interferon produced in vitro as a quantitative indicator of cell-mediated immunity. Microbiol Immunol. 1979;23(12):1169–1177. doi: 10.1111/j.1348-0421.1979.tb00549.x. [DOI] [PubMed] [Google Scholar]
- Osborn J. E., Walker D. L. The role of individual spleen cells in the interferon response of the intact mouse. Proc Natl Acad Sci U S A. 1969 Apr;62(4):1038–1045. doi: 10.1073/pnas.62.4.1038. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shimokata K. Studies on the pathogenicity of human-origin parainfluenza virus in the brain of mice. Microbiol Immunol. 1978;22(9):535–543. doi: 10.1111/j.1348-0421.1978.tb00401.x. [DOI] [PubMed] [Google Scholar]
- Takahashi T., Old L. J., Boyse E. A. Surface alloantigens of plasma cells. J Exp Med. 1970 Jun 1;131(6):1325–1341. doi: 10.1084/jem.131.6.1325. [DOI] [PMC free article] [PubMed] [Google Scholar]