Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 May;28(2):620–623. doi: 10.1128/iai.28.2.620-623.1980

Peripheral infection in culture of rat sensory neurons by herpes simplex virus.

R J Ziegler, R E Herman
PMCID: PMC550978  PMID: 6249745

Abstract

The peripheral infection of neurons from dissociated rat sensory ganglia by herpes simplex virus was studied with a newly developed tissue culture system. The results indicated that the virus arrives at the neuronal soma by an axoplasmic route and that at least some of these neurons are productively infected since eventually all cells in the culture appeared to be destroyed by the virus. This system showed promise in elucidating the possible roles of various effector cells, antiviral antibody, or antiviral compounds in the mechanism of herpes simplex virus latency.

Full text

PDF
620

Images in this article

620Fig. 1
on p.620
621Fig. 2
on p.621
622Fig. 3
on p.622

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baringer J. R. Herpes simplex virus infection of nervous tissue in animals and man. Prog Med Virol. 1975;20:1–26. [PubMed] [Google Scholar]
  2. Baringer J. R. Recovery of herpes simplex virus from human sacral ganglions. N Engl J Med. 1974 Oct 17;291(16):828–830. doi: 10.1056/NEJM197410172911606. [DOI] [PubMed] [Google Scholar]
  3. Baringer J. R., Swoveland P. Recovery of herpes-simplex virus from human trigeminal ganglions. N Engl J Med. 1973 Mar 29;288(13):648–650. doi: 10.1056/NEJM197303292881303. [DOI] [PubMed] [Google Scholar]
  4. Campenot R. B. Local control of neurite development by nerve growth factor. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4516–4519. doi: 10.1073/pnas.74.10.4516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cook M. L., Stevens J. G. Latent herpetic infections following experimental viraemia. J Gen Virol. 1976 Apr;31(1):75–80. doi: 10.1099/0022-1317-31-1-75. [DOI] [PubMed] [Google Scholar]
  6. Cook M. L., Stevens J. G. Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun. 1973 Feb;7(2):272–288. doi: 10.1128/iai.7.2.272-288.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Galloway D. A., Fenoglio C., Shevchuk M., McDougall J. K. Detection of herpes simplex RNA in human sensory ganglia. Virology. 1979 May;95(1):265–268. doi: 10.1016/0042-6822(79)90429-x. [DOI] [PubMed] [Google Scholar]
  8. Hirsch M. S., Zisman B., Allison A. C. Macrophages and age-dependent resistance to Herpes simplex virus in mice. J Immunol. 1970 May;104(5):1160–1165. [PubMed] [Google Scholar]
  9. Kristensson K., Ghetti B., Wiśniewski H. M. Study on the propagation of Herpes simplex virus (type 2) into the brain after intraocular injection. Brain Res. 1974 Apr 5;69(2):189–201. doi: 10.1016/0006-8993(74)90001-8. [DOI] [PubMed] [Google Scholar]
  10. Kristensson K., Vahlne A., Persson L. A., Lycke E. Neural spread of herpes simplex virus types 1 and 2 in mice after corneal or subcutaneous (footpad) inoculation. J Neurol Sci. 1978 Feb;35(2-3):331–340. doi: 10.1016/0022-510x(78)90013-8. [DOI] [PubMed] [Google Scholar]
  11. Lodmell D. L., Niwa A., Hayashi K., Notkins A. L. Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med. 1973 Mar 1;137(3):706–720. doi: 10.1084/jem.137.3.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McKendall R. R., Vogelzang N., Jackson G. G. Herpes virus latency in spinal ganglia of mice without illness. Proc Soc Exp Biol Med. 1974 Sep;146(4):1093–1096. doi: 10.3181/00379727-146-38251. [DOI] [PubMed] [Google Scholar]
  13. Price R. W., Schmitz J. Reactivation of latent herpes simplex virus infection of the autonomic nervous system by postganglionic neurectomy. Infect Immun. 1978 Feb;19(2):523–532. doi: 10.1128/iai.19.2.523-532.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stevens J. G., Cook M. L. Latent herpes simplex virus in spinal ganglia of mice. Science. 1971 Aug 27;173(3999):843–845. doi: 10.1126/science.173.3999.843. [DOI] [PubMed] [Google Scholar]
  15. Stevens J. G., Cook M. L. Maintenance of latent herpetic infection: an apparent role for anti-viral IgG. J Immunol. 1974 Dec;113(6):1685–1693. [PubMed] [Google Scholar]
  16. Tenser R. B., Hsiung G. D. Pathogenesis of latent herpes simplex virus infection of the trigeminal ganglion in guinea pigs: effects of age, passive immunization, and hydrocortisone. Infect Immun. 1977 Apr;16(1):69–74. doi: 10.1128/iai.16.1.69-74.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WHEELER C. E. Further studies on the effect of neutralizing antibody upon the course of herpes simplex infections in tissue culture. J Immunol. 1960 Apr;84:394–403. [PubMed] [Google Scholar]
  18. Walz M. A., Price R. W., Notkins A. L. Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science. 1974 Jun 14;184(4142):1185–1187. doi: 10.1126/science.184.4142.1185. [DOI] [PubMed] [Google Scholar]
  19. Walz M. A., Yamamoto H., Notkins A. L. Immunological response restricts number of cells in sensory ganglia infected with herpes simplex virus. Nature. 1976 Dec 9;264(5586):554–556. doi: 10.1038/264554a0. [DOI] [PubMed] [Google Scholar]
  20. Warren K. G., Brown S. M., Wroblewska Z., Gilden D., Koprowski H., Subak-Sharpe J. Isolation of latent herpes simplex virus from the superior cervical and vagus ganglions of human beings. N Engl J Med. 1978 May 11;298(19):1068–1069. doi: 10.1056/NEJM197805112981907. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES